标题：妊娠期高血压疾病患者胎儿脐血中MMP-1及TIMP-1的表达及意义

      作者：邓春雷，曹桂荣
    （十堰市太和医院妇产科，湖北 十堰 442000）

      卷次： 2013年24卷8期

      【摘要】 目的 探讨脐血血清中MMP-1及TIMP-1的表达与妊娠期高血压疾病发生及疾病严重程度的相
关性。方法 选取43例妊娠期高血压疾病患者为实验组，其中妊娠期高血压18例，轻度子痫前期9例，重度子
痫前期 16例，同期 30例正常晚孕孕妇为对照组。采用酶联免疫吸附试验(ELISA)检测脐血血清中MMP-1及
TIMP-1的表达。结果 妊娠期高血压疾病组脐血血清中MMP-1表达低于对照组(P<0.05)，妊娠期高血压组、
轻度子痫前期组、重度子痫前期组MMP-1表达逐渐下降，三组间两两比较差异均有统计学意义(P<0.05)，
TIMP-1的表达差异无统计学意义(P>0.05)。结论 MMP-1与妊娠期高血压疾病的发生和疾病严重程度之间存
在相关性，MMP-1、TIMP-1可能参与妊娠期高血压疾病的发生与发展。

      【关键词】 妊娠期高血压疾病；MMP-1；TIMP-1；脐血

      【中图分类号】 R714.24+6 【文献标识码】 A 【文章编号】 1003—6350（2013）08—1162—03


Expression and significance of matrix metallopreteinases-1 and tissue inhibitor of metalloproteinases-1 in
umbilicus serum of patients with hypertensive disorders during pregnancy.
DENG Chun-lei, CAO Gui-rong.
Department of Obstetrics and Gynecology, Taihe Hospital in Shiyan City, Shiyan 442000, Hubei, CHINA

【Abstract】 Objective To investigate the relationship between the expression of matrix metallopreteinas-
es-1 (MMP-1), tissue inhibitor of metalloproteinases-1 (TIMP-1) and hypertensive disorders during pregnancy.
Methods Forty-three patients with hypertensive disorders during pregnancy were enrolled as the study group, in-
cluding 18 patients with gestational hypertension, 9 with mild preeclampsia, and 16 with severe preeclampsia. Thirty
normal pregnant women were collected as the control group. Enzyme linked immunosorbent assay was used to ana-
lyze the expression of MMP-1 and TIMP-1 in umbilicus serum. Results The expression of MMP-1 in the study
group was significantly lower than that in the control group (P<0.05). And the more serious was hypertensive disor-
ders during pregnancy, the lower was the expression of MMP-1. There was no statistically significant difference be-
tween the two groups in the expression of TIMP-1. Conclusion There was a close relationship between the expres-
sion of MMP-1 and hypertensive disorders during pregnancy. MMP-1 and TIMP-1 might play an important role in
the development of hypertensive disorders during pregnancy.

      【Key words】 Hypertensive disorders during pregnancy; Matrix Metalloproteinases-1 (MMP-1); Tissue Inhibi-
tor of Metalloproteinases-1 (TIMP-1); Umbilicus serum