标题：673例结核病患者血清肿瘤标志物检测结果分析

      作者：赵红英 1，苏国生 2，罗晓璐 2，黄 亮 2
    (1.广西壮族自治区人民医院检验科，广西 南宁 530001；
2.南宁市第四人民医院检验科，广西 南宁 530023）

      卷次： 2013年24卷8期

      【摘要】 目的 分析结核病患者血清肿瘤标志物的检测结果。方法 选取 2012年 1~10月在南宁市第四
人民医院住院的结核病患者 673例作为研究对象，利用电化学发光检测血清AFP、CEA、CA125、CA199等四
项肿瘤标志物的浓度，分析各项指标的阳性率及患者年龄之间的关系。结果 在 673例结核病患者中有 11
例AFP浓度水平升高，占受检人数的 1.63%，有 97例CEA浓度水平升高，占 14.41%，有 149例CA199浓度水
平升高，占 22.14%，有 311例CA125浓度水平升高，占 46.21%，升高的各项指标平均浓度与正常的平均浓度
比较差异均具有统计学意义(P均<0.01)。在年龄比较中，浓度升高组和正常组比较，差异均具有统计学意义
(P均<0.01)。结论 常规对结核病患者进行肿瘤标志物的检测可有效、及时的发现结核病合并其他肿瘤的情
况，从而做到早发现、早治疗，以保证患者健康，减少死亡病例的发生。

      【关键词】 结核病；肿瘤标志物；阳性率

      【中图分类号】 R52 【文献标识码】 A 【文章编号】 1003—6350（2013）08—1157—03


Detection of serum tumor markers in 673 patients of tuberculosis.
ZHAO Hong-ying 1, SU Guo-sheng 2, LUO
Xiao-lu 2, HUANG Liang 2. 1. Department of Clinical Laboratory, People's Hospital of Guangxi Zhuang Autonomous
Region, Nanning 530001, Guangxi, CHINA; 2. Department of Clinical Laboratory, the Fourth People's Hospital of
Nanning, Nanning 530023, Guangxi, CHINA

【Abstract】 Objective To analyze the detection results of serum tumor markers in patients with tuberculosis.
Methods Six hundred and seventy-three patients with tuberculosis in the Fourth People's Hospital of Nanning from
January 2012 to October were selected as the research objects. The serum levels of AFP, CEA, CA125 and CA199
were detected using electrochemical luminescence. The positive rate of each indicator, and the relationship between
the patients with age were analyzed. Results In 673 patients of tuberculosis, AFP levels increased in 11 patients
(1.63%), CEA levels increased in 97 patients (14.41%), CA199 levels increased in 149 patients (22.14%), CA125 lev-
els increased in 311 patients (46.21%). The average levels of the indicators showed statistically significant difference
with the normal average concentration (P<0.01). Patients with increased concentration showed statistically significant
difference with the patients with normal concentration in age (P<0.01). Conclusion Routine detection of tumor
markers for tuberculosis patients can effectively detect the complicated tumors of tuberculosis, which enable us to per-
form early treatment to ensure patients’health and reduce the occurrence of death.