标题：结直肠癌术后腹腔引流液CEA、CA125、CA19-9的检测与

      作者：肿瘤淋巴转移的相关性分析
    王碧玉 1，庄晓泉 2，黄 芳 1，赵 勇 2，向俾庭 2
（桂林市人民医院检验科 1、普通外科 2，广西 桂林 541002）

      卷次： 2013年24卷8期

      【摘要】 目的 探讨结直肠癌术后腹腔引流液中肿瘤标志物CEA、CA125、CA19-9浓度与肿瘤淋巴结转移
的相关性。方法 检测 55例结直肠癌患者术后第 1、2天腹腔引流液中肿瘤标志物CEA、CA125、CA19-9的浓
度，并按照有无淋巴结转移进行分组。结果 术后第 1、2天无淋巴结转移组与有淋巴结转移组腹腔引流液中
CEA浓度比较差异有统计学意义，无淋巴结转移组CEA浓度低于有淋巴结转移组，CA19-9、CA125浓度比较差
异无统计学意义；无淋巴结转移组第1、2天腹腔引流液CEA、CA125浓度比较差异有统计学意义，第2天CEA浓
度低于第1天，CA125浓度高于第1天，CA19-9比较差异无统计学意义；有淋巴结转移组术后第1、2天腹腔引流
液中CEA、CA19-9、CA125浓度比较差异无统计学意义。结论 结直肠癌患者术后早期腹腔引流液中CEA浓度
的表达与肿瘤的淋巴结转移具有正相关性，而CA19-9和CA125临床价值不大。

      【关键词】 结直肠癌；癌胚抗原；糖类抗原CA19-9；糖类抗原CA125；淋巴结转移

      【中图分类号】 R735 【文献标识码】 A 【文章编号】 1003—6350（2013）08—1154—03


Levels of CEA, CA125, CA19-9 in intraperitoneal drainage after resection of colorectal cancer and their
relationship with lymph node metastasis.
WANG Bi-yu 1, ZHUANG Xiao-quan 2, HUANG Fang 1, ZHAO Yong 2,
XIANG Bi-ting 2. Depaetment of Clinical Laboratory 1, Department of General Surgery 2, People's Hospital of Guilin, Guilin
541002, Guangxi, CHINA

【Abstract】 Objective To investigate the levels of tumor markers (CEA, CA125, CA19-9) in intraperitoneal
drainage after resection of colorectal cancer, and their relationship with lymph node metastasis. Methods Fifty pa-
tients with colorectal cancer were enrolled in this study. The levels of tumor markers (CEA, CA125, CA19-9) were de-
tected on the first, second day after resection. The patients were divided into two groups: group A (with lymph node
metastasis) and group B (without lymph node metastasis). Results After resection, the levels of CEA was significant-
ly higher in group A than group B, and the levels of CA19-9 and CA125 showed no statistically significant difference
between the two groups. In group B, the levels of CEA was significantly higher on the first day than the second day af-
ter resection, and the levels of CA125 was significantly lower on the first day, with no statistically significant differ-
ence in the levels of CA19-9. In group A, the levels of CEA, CA19-9, CA125 showed no statistically significant dif-
ference between the first day and the second day. Conclusion The levels of CEA in intraperitoneal drainage after re-
section in patients with colorectal cancer is positively correlated with lymph node metastasis, while CA19-9 and
CA125 have little clinical value.

      【Key words】 Colorectal cancer; Carcinoembryonic antigen (CEA); Carbohydrate antigen (CA19-9); Carbohy-
drate antigen (CA125); Lymph node metastasis
基金项目：桂林市科技局科研基金项目(编号:20120121-5-2)