标题：妊娠期糖尿病孕妇血浆及脐血Betatrophin水平的变化及临床意义

      作者：王国华 1，刘亚琼 1，杨夫艳 1，金钧 2
    (连云港市第一人民医院妇产科 1、检验科 2，江苏 连云港 222000)

      卷次： 2016年27卷7期

      【摘要】 目的 探讨妊娠期糖尿病患者母血及脐血Betatrophin水平的变化，并分析其与临床、生化指标的相
关性。方法 选取我院2013年6月至2015年6月收治的30例妊娠期糖尿病患者为研究对象(GDM组)，30例正常
健康妊娠妇女为对照(NGT组)，采用酶联免疫吸附试验(ELISA)测定母血及脐血Betatrophin水平。结果 妊娠期糖
尿病患者母血及脐血Betatrophin水平均明显高于正常妊娠妇女，差异有统计学意义(P<0.05)；GDM组患者血清
Betatrophin浓度与孕期体质量指数的增加量(ΔBMI)、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、总胆固醇
(TC)及脐血 Betatrophin呈正相关 (r=0.344，P=0.026；r=0.317，P=0.041；r=0.364，P=0.018；r=0.644，P<0.001；r=
0.352，P=0.022)。结论 妊娠期糖尿病患者母血及脐血Betatrophin水平升高可能是胰岛素抵抗的一种代偿性机
制，Betatrophin可能成为治疗各种类型糖尿病的新靶点。

      【关键词】 Betatrophin；妊娠期糖尿病；胰岛素抵抗；临床意义

      【中图分类号】 R714.256 【文献标识码】 A 【文章编号】 1003—6350（2016）07—1070—03


Changes and clinical significance of Betatrophin level in plasma and cord blood in pregnant women with
gestational diabetes mellitus.
WANG Guo-hua 1, LIU Ya-qiong 1, YANG Fu-yan 1, JIN Jun 2. Department of Gynecology
and Obsterics 1, Department of Clinical Laboratory 2, the First People's Hospital of Lianyungang City, Lianyungang 222000,
Jiangsu, CHINA

【Abstract】 Objective To investigate the changes of betatrophin level in plasma and cord blood of pregnant
women with gestational diabetes mellitus (GDM), and to analyze the relationship between Betatrophin and clinical and
biochemical indexes. Methods Thirty patients with GDM in our hospital between June 2013 and June 2015 were se-
lected as the research subjects (GDM group). In addition, thirty healthy pregnant women in the same period were select-
ed as the control group (NGT group). Enzyme linked immunosorbent assay (ELISA) was applied to determine the levels
of Betatrophin in plasma and cord blood. Results The Betatrophin levels in plasma and cord blood in GDM group
were significantly higher than those in NGT group (P<0.05). Betatrophin concentrations in the GDM group were posi-
tively correlated with the increase in body mass index during pregnancy (ΔBMI), insulin resistance index (HOMA-IR),
triglyceride (TG), total cholesterol (TC) and betatrophin levels in cord blood (r=0.344, P=0.026; r=0.317, P=0.041; r=
0.364, P=0.018; r=0.644, P<0.001; r=0.352, P=0.022). Conclusion Elevated levels of Betatrophin in plasma and cord
blood of GDM patients may be a compensatory mechanism of insulin resistance, and Betatrophin might serves as a new
target for the treatment of various types of diabetes.

      【Key words】 Betatrophin; Gestational diabetes mellitus; Insulin resistance; Clinical significance
·论 著·
6350.2016.07.014