标题：卵巢癌患者血清VEGF、CA125的表达及其与疾病进展的关系

      作者：黄 芳
    （桂林市人民医院检验科，广西 桂林 541002）

      卷次： 2013年24卷7期

      【摘要】 目的 探讨血管内皮细胞生长因子(VEGF)和糖类抗原（CA125）在卵巢癌患者血清中的表达及其
与疾病进展的关系。方法 检测 50例卵巢癌患者、50例卵巢良性疾病患者和 60例健康女性血清中VEGF、
CA125的水平，将卵巢癌患者以有无淋巴结转移分为两组，同时按FIGO (1987年)进行临床分期：Ⅰ期10例、Ⅱ期
18例、Ⅲ期12例，Ⅳ期10例；用酶联法检测VEGF，用电化学发光法检测CA125。结果 卵巢癌组各项检测指标
与良性疾病组和正常对照组比较差异均有统计学意义(P<0.01)，而良性组与健康对照组比较VEGF差异无统计
学意义( P>0.05)，CA125差异有统计学意义(P<0.01)；卵巢癌患者有无淋巴结转移血清VEGF、CA125水平比较
差异均有统计学意义(P<0.01)；不同临床分期卵巢癌患者血清VEGF、CA125水平比较，Ⅳ期与Ⅲ期，Ⅲ期与Ⅰ、
Ⅱ期比较VEGF、CA125水平差异均有统计学意义（P<0.01）。结论 联合检测血清VEGF、CA125对卵巢癌的
诊断、病情评估以及预后判断具有重要价值。

      【关键词】 血管内皮细胞生长因子VEGF；糖类抗原CA125；卵巢癌

      【中图分类号】 R737.31 【文献标识码】 A 【文章编号】 1003—6350（2013）07—1002—03


Expression of VEGF, CA125 in the serum of patents with ovarian cancer and its relationship with disease
progression.
HUANG Fang. Department of Clinical Laboratory, the People's Hospital of Guilin City, Guilin 541002,
Guangxi, CHINA

【Abstract】 Objective To study the expression of vascular endothelial growth factor (VEGF), carbohydrate
antigen (CA-125) in the serum of patents with ovarian cancer, and to investigate the relationship between VEGF,
CA125 expression and disease progression of ovarian cancer. Methods The levels of VEGF and CA125 were detect-
ed 50 patients with ovarian cancer, 50 patients with benign ovarian diseases and 60 healthy women. The patients with
ovarian cancer were divided into two groups according to lymphnode metastasis and into four periods according to FI-
GO (1987): 10 cases ofⅠperiod, 18 cases of Ⅱperiod, 12 cases of Ⅲ period, 10 cases of Ⅳperiod. The levels of
VEGF were detected by ELISA, and the levels of CA125 were detected by chemoluminescence. Results The levels
of VEGF and CA125 in the patients with ovarian cancer showed statistically significant difference with those in the pa-
tients with benign ovarian diseases and the healthy women (P<0.01). The levels of VEGF showed no statistically sig-
nificant difference between the patients with benign ovarian diseases and the healthy women (P>0.05), while the lev-
els of CA125 showed statistically significant difference (P<0.01). There was statistically significant difference in the
levels of VEGF and CA125 between Ⅳ period and Ⅲ period, between Ⅲ period and Ⅰ, Ⅱperiod (P<0.01). There
was statistically significant difference the levels of VEGF and CA125 between the patients with or without lymphnode
metastasis (P<0.01). Conclusion Combined detection of VEGF, CA125 in serum can be used as an important refer-
ence index for the diagnosis of ovarian cancer, the evaluation of disease situation and prognosis.

      【Key words】 Vascular endothelial growth factor (VEGF); Carbohydrate antigen (CA-125); Ovarian cancer