标题：胃癌患者凝血功能和D-二聚体水平的变化及其临床意义

      作者：党颖徐，段 欣，李 英
    （河南大学附属南石医院检验科，河南 南阳 473006）

      卷次： 2013年24卷7期

      【摘要】 目的 探讨凝血功能和D-二聚体水平在胃癌患者中的检测价值。方法 选择我院胃癌患者40例
作为观察组，上述患者均经体格检查、影像学检查、病理组织学检查等确诊。选择同期健康体检者40例作为对照
组。本文所选对象均取清晨空腹抗凝血浆测定凝血酶原时间（PT）、活化部分凝血活酶时间(APTT)、凝血酶时间
(TT)、纤维蛋白原(Fib)和D-二聚体(D-D)水平。结果 胃癌组PT、APTT较对照组延长，差异有统计学意义（均
P <0.05）；TT较对照组长，但差异无统计学意义（P>0.05）；观察组Fib、D-二聚体水平较对照组明显升高，差异有
统计学意义（均P<0.01）。结论 胃癌患者凝血功能发生紊乱，检测相关凝血功能指标及D-二聚体水平对其病
情观察和临床治疗具有一定的指导意义。

      【关键词】 胃癌；凝血功能；D-二聚体

      【中图分类号】 R735.2 【文献标识码】 A 【文章编号】 1003—6350（2013）07—1000—02


Change of coagulation function and D-dimer in patients with gastric cancer and its clinical significance.
DANG
Ying-xu, DUAN Xin, LI Ying. Department of Clinical Laboratory, Nanshi Hospital Affiliated to Henan University,
Nanyang 473006, Henan, CHINA

【Abstract】 Objective To explore the clinical significance of coagulation function and D-dimer (D-D) in pa-
tients with gastric cancer. Methods The plasma prothrombin time (PT), activated partial thromboplastin time
(APTT), thrombin time (TT), fibrinogen (Fib) and D-D were determined in 40 healthy individuals (the control group)
and in 40 patients with gastric cancer (the study group). Results The plasma PT, APTT were significantly longer in
the study group than the control group (P<0.05). TT of the study group was slightly longer than that of the control
group, with no statistically significant difference (P>0.05). Fib and D-D levels of the study group were significantly
higher than those of the control group (P<0.01). Conclusion Patients with gastric cancer exhibit disorder of coagula-
tion function. The detection of coagulation function and D-D in patients with gastric cancer plays important role for
the observation of disease condition and the clinical treatment.

      【Key words】 Gastric cancer; Coagulation function; D-dimer (D-D)
·论 著·