标题：妊娠妇女不同孕周的外周血雌二醇动态水平分析

      作者：唐超人，韩宇春，马双凤，徐远霞，韦云慧
    (柳州市潭中人民医院妇产科，广西 柳州 432000)

      卷次： 2016年27卷7期

      【摘要】 目的 动态观察妊娠妇女不同孕周的外周血雌二醇水平，评估其对妊娠结局的预测作用。方法 选
取2012年1月至2014年12月期间我院接诊的3 901例孕4~15周的妊娠妇女为研究对象，在征得妊娠妇女同意的原
则下进行外周血雌二醇的动态监测，分析不同孕周期间雌二醇水平波动状况，并通过SPSS18.0软件进行统计分析
各孕周的外周血雌二醇范围，评估不同孕周雌二醇水平对妊娠结局的预测能力。结果 3 901例妊娠妇女不同孕
周的外周血雌二醇水平随着孕周的增加而缓慢上升，其均值水平从第4周的253 pg/mL开始增长，至第12周达到最
高峰1 975 pg/mL，13周之后有所回落；而各孕周间增幅高低也不一，其均值水平从第1周间增长106 pg/mL开始增
长至第 3周间达到增幅 376 pg/mL，然后出现增幅变缓，在小于 12周前期间平均增值 246 pg/mL，在大于或等于 13
周略有向上波动，但总体呈现下降趋势。结论 妊娠妇女不同孕周的外周血雌二醇水平与妊娠密切相关，可以作
为预测妊娠结局的重要指标，尤其在12周前，其增长速度与孕周呈正相关性。

      【关键词】 雌二醇；孕周；妊娠结局；外周血

      【中图分类号】 R714.14 【文献标识码】 A 【文章编号】 1003—6350（2016）07—1067—03


Analysis of the dynamic level of estradiol in the peripheral blood of pregnant women with different gestational
weeks.
TANG Chao-ren, HAN Yu-chun, MA Shuang-feng, XU Yuan-xia, WEI Yun-hui. Department of Gynaecology and
Obstetrics, Tanzhong General Hospaital of Liuzhou, Liuzhou 432000, Guangxi, CHINA

【Abstract】 Objective To observe the level of estradiol in the peripheral blood of pregnant women at the differ-
ent gestational weeks, and to evaluate the outcome of pregnancy. Methods A total of 3 901 pregnant women with 4~15
weeks of pregnancy in our hospital from January 2012 to December 2014 were enrolled in the study. The dynamic moni-
toring of estradiol was performed to analyze the fluctuation of estradiol levels in different pregnant periods. The range of
estradiol in the peripheral blood was analyzed by SPSS18.0 software in order to evaluate the predictive role of estradiol
levels in different gestational weeks on the outcome of pregnancy. Results In the 3 901 pregnant women, the levels of
estradiol increased slowly with the increase of the gestational weeks, and the mean levels began to grow from 253 pg/mL
in the fourth week to the peak of 1 975 pg/mL in the twelfth week, which then tended to fall after 13 weeks of gestation.
The increased levels of different gestational weeks were different, and the increase amplitude of mean levels increased
from 106 pg/mL in the first week to 376 pg/mL in the third week, and then started to slow down or even fall back. The
average increase amplitude was 246 pg/mL in the period of less than 12 weeks, and the levels after 13 weeks generally
showed a downward trend with slightly upward fluctuations. Conclusion The level of estradiol in the pregnant women
is closely related with the pregnancy in different gestational weeks. It can be used as an important index to predict the
outcome of pregnancy, especially before 12 weeks.

      【Key words】 Estradiol; Gestational weeks; Outcome of pregnancy; Peripheral blood
·论 著·
6350.2016.07.013