标题：瑞舒伐他汀联合恩替卡韦治疗慢性乙型肝炎合并脂肪肝的疗效观察

      作者：陆振亚
    （无锡市第五人民医院药剂科，江苏 无锡 214005）

      卷次： 2013年24卷7期

      【摘要】 目的 观察瑞舒伐他汀联合恩替卡韦治疗慢性乙型肝炎合并脂肪肝的疗效。方法 入选58例慢
性乙型肝炎合并脂肪肝的患者随机分为治疗组（30例）和对照组（28例）。对照组给予恩替卡韦治疗48周，治疗
组相同给予恩替卡韦治疗的情况下，在第12~24周每晚加服瑞舒伐他汀联合治疗。两组均给予基础对症支持治
疗，疗程为48周。在治疗前、治疗后的各个时间点检测血清ALT水平、HBV-DNA、甘油三酯(TG)、总胆固醇(TC)、
LDL-C、HDL-C进行比较。结果 两组肝功能指标、HBV DNA、血清ALT水平均有改善，其中治疗组的血清ALT
水平、TC、TG、LDL-C、HDL-C的改善明显优于对照组(P<0.05)。结论 瑞舒伐他汀联合恩替卡韦治疗慢性乙型
肝炎合并脂肪肝的患者在血清ALT水平改善上有明显效果，对于脂肪肝疗效显著，且不良反应少。

      【关键词】 恩替卡韦；瑞舒伐他汀；慢性乙型肝炎；脂肪肝；ALT

      【中图分类号】 R512.6+2 【文献标识码】 A 【文章编号】 1003—6350（2013）07—0949—03


Therapeutic effect of rosuvastain combined with entecavir in the treatment of chronic hepatitis B complicated
with fatty liver.
LU Zhen-ya. Department of Pharmacy, The Fifth People's Hospital of Wuxi City, Wuxi 214005, Jiangsu,
CHINA

【Abstract】 Objective To study the therapeutic efficacy of rosuvastain combined with entecavir for treating
patients of chronic hepatitis B (CHB) complicated with fatty liver. Methods Fifty-eight patients of chronic hepatitis
B complicated with fatty liver were randomly assigned into two groups. The control group (n=28) was treated by ente-
cavir for 48 weeks, and the study group (n=30) applied rosuvastatin every night from the 12th to 24th week based on the
control group. The serum ALT, HBV-DNA, TG, TC, LDL-C, and HDL-C of the patients before and after treatment
were compared. Results The indices of liver function, HBV-DNA, serum ALT of the two group were improved signifi-
cantly (P<0.05), and the improvement of serum ALT, TG, TC, LDL- C, HDL-C of the study group was significantly bet-
ter than that of the study group (P<0.05). Conclusion For treating patients of chronic hepatitis B complicated with fat-
ty liver, rosuvastain combined with entecavir has significant effect in improving serum ALT, with fewer side effects.