标题：血浆NT-proBNP水平对急性心肌梗死患者预后及心功能的预测价值
作者：许振培
（海口市府城医院内三科，海南 海口 571100）
卷次：
2013年24卷6期
【摘要】 目的 探讨血浆氨基末端脑钠肽前体(NT-proBNP)水平对急性心肌梗死近期预后及心功能的预测
作用。方法 将我院收治的52例急性ST段抬高型心肌梗死患者作为研究对象，所有患者于发病26~48 h测定血
浆NT-proBNP和左心室射血分数（LVEF），根据LVEF将患者分为心功能正常组24例（LVEF≥0.50）和心功能不全组
28例（LVEF＜0.50）；所有患者随诊3个月，死亡5例作为死亡组，存活47例作为存活组，比较各组患者NT-proBNP水
平。结果 ①心功能不全组患者NT-proBNP水平明显高于心功能正常组患者NT-proBNP水平(P<0.05)。②死亡组
患者NT-proBNP水平明显高于存活组NT-proBNP水平（P<0.05）。结论 急性心肌梗死患者血浆NT-proBNP水平
与心功能及近期预后有关，血浆NT-proBNP对患者心功能和近期预后有一定的预测价值。
【关键词】 急性心肌梗死；血浆氨基末端脑钠肽前体；左心室射血分数；心功能
【中图分类号】 R542.2+2 【文献标识码】 A 【文章编号】 1003—6350（2013）06—0851—02
Prognostic and predictive value of plasma NT-proBNP levels for cardiac function in patients with acute myocardial
infarction.
XUZhen-pei. The Third Internal Medicine of Fucheng Hospital, Haikou 571100, Hainan, CHINA
【Abstract】 Objective To investigate the prognostic and predictive value of plasma NT-proBNP levels for
cardiac function in patients with acute myocardial infarction. Methods 52 patients with acute ST-segment elevation
myocardial infarction were selected as study objects, and plasma NT-proBNP and left ventricular ejection fraction
(LVEF) were determined in all the patients determine at the onset of 26 ~ 48h. According to LVEF, 52 patients were di-
vided into the normal group, 24 cases (LVEF≥0.50) and cardiac dysfunction group, 28 patients (LVEF<0.50). All the
patients had been followed up for 3 months, 5 people died as a death group, 47 people survived, as a survival group.
Results NT-proBNP level was significantly higher in the cardiac dysfunction group than that in the normal cardiac
function (P<0.05). NT-proBNP level was significantly higher in death group than that in the survival group (P<0.05).
Conclusion Plasma NT-proBNP level in the patient with acute myocardial infarction is relative with heart function
and prognosis, andhas the predictive value for cardiac function and prognosis.
【Key words】 Acute myocardial infarction; Plasma amino-terminal pro-brain natriuretic peptide precursor; Left
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