标题：七氟烷和丙泊酚麻醉对老年结直肠癌患者认知功能的影响

      作者：曹 雷，李成辉
    （北京市中日友好医院麻醉科，北京 100029）

      卷次： 2013年24卷6期

      【摘要】 目的 比较七氟烷和丙泊酚麻醉对老年结直肠癌患者认知功能的影响。方法 选择2010年7月
至 2012年 7月在我院普外科住院治疗的 126例老年结直肠癌患者为研究对象，运用随机数字表法将符合纳入
标准和排除标准的患者分为A组和B组，A组患者麻醉诱导后静脉靶控输注丙泊酚维持麻醉，B组患者麻醉诱
导后给予吸入七氟烷维持麻醉，采用简易精神状态量表(MMSE)评价患者的认知功能变化和其他药物不良反应
情况。结果 B组患者术后应答后 1 h、6 h和 12 h的评分均明显低于A组患者相应时点的评分(P<0.05)，但是，
在应答后 24 h，两组患者的MMSE评分恢复至麻醉前水平。B组患者恶心呕吐和眩晕发生率明显低于A组患
者 (P<0.05)，对手术满意度明显高于A组患者(P<0.05)。结论 与丙泊酚麻醉相比，吸入七氟烷维持麻醉老年结
直肠癌术后，患者会出现可逆性的认知功能障碍，但是麻醉安全，不良反应少。

      【关键词】 七氟烷；吸入麻醉；结直肠癌；认知功能障碍

      【中图分类号】 R735 【文献标识码】 A 【文章编号】 1003—6350（2013）06—0834—03


Effect of sevoflurane and propofol anesthesia on the cognitive function of elderly patients with colorectal
cancer.
CAO Lei, LI Cheng-hui. Department of Anesthesiology, Beijing Sino-Japanese Friendship Hospital, Beijing
100029, CHINA

【Abstract】 Objective To investigate the effect of sevoflurane and propofol anesthesia on the cognitive func-
tion of elderly patients with colorectal cancer. Methods The clinical data of 126 elderly patients with colorectal can-
cer who were treated in the Department of General Surgery in our hospital from July 2010 to July 2012 were collected,
The patients were divided into group A and group B according to random number table. Patients in group A were main-
tained by propofol after induction of anesthesia, but patients in B group was maintained by sevoflurane after induction
of anesthesia, The patients were surveyed by self-designed general data questionnaire and Mini Mental State Examina-
tion (MMSE) for cognitive function. The adverse reactions were observed in the two groups. Results The scores of
MMSE in group B were lower than that in group A one hour, six hours and twelve hours after response (P<0.05), but
the scores of the two groups recovered to the level before anesthesia twenty-four hours after response. The incidences
of nausea, vomiting and dizziness in group B was significantly lower than those in the group A (P<0.05). The pa-
tients'satisfaction degree in group B was significantly higher than that in group A (P<0.05). Conclusion Sevoflurane
inhalation anesthesia can cause reversible cognitive dysfunction in elderly patients with colorectal cancer, which is
safe and with less adverse reactions.

      【Key words】 Sevoflurane; Inhalation anesthesia; Colorectal cancer; Cognitive dysfunction