标题：核黄素磷酸钠注射液在手足口病中的应用

      作者：陈 军，王险峰，王艳荣，李志辉
    （深圳市第三人民医院儿科，广东 深圳 518112）

      卷次： 2013年24卷6期

      【摘要】 目的 观察核黄素磷酸钠注射液治疗手足口病的临床疗效。方法 选取 2011年 3月至 2012年 7
月在深圳市第三人民医院确诊为手足口病的64例住院患儿，根据治疗方法分为治疗组（33例）和对照组（31例），
两组均接受常规补液及对症治疗，治疗组加用核黄素磷酸钠注射液10 mg/d，1次/d，静脉滴注5~7 d后，对两组患
儿的疱疹消失时间、食欲、体温等变化及药物不良反应进行临床分析。结果 治疗组患儿疱疹好转消失时间为
食欲和体温恢复正常时间分别为(4.45±0.51) d、(3.11±0.1) d、(3.19±0.6) d，均短于对照组相应的三项指标恢复正常
的时间 [(6.55±1.51) d、(4.09±0.83) d、(5.0±1.29) d]，差异有统计学意义(P<0.05)，治疗组显效率(72.7%)及总有效率
(90.9%)均高于对照组(41.9%、90.3%)，且差异有统计学意义(P<0.05)，治疗期间未见明显副反应。结论 核黄素
磷酸钠注射液辅助治疗手足口病疗效显著。

      【关键词】 手足口病；核黄素磷酸钠；疗效

      【中图分类号】 R512.5 【文献标识码】 A 【文章编号】 1003—6350（2013）06—0826—03


Application of Rlboflavin Sodium Phosphate Injection in the treatment of hand, foot and mouth disease.
CHEN Jun,
WANG Xian-Feng, WANG Yan-rong, LI Zhi-hui. Department of Pediatrics, Shenzhen Third People's Hospital, Shenzhen
518112, Guangdong, CHINA

【Abstract】 Objective To evaluate clinical efficacy of Rlboflavin Sodium Phosphate Injection in the treat-
ment of hand, foot and mouth disease (HFMD). Methods Sixty-four children of HFMD in Shenzhen Third People's
Hospital from Mar. 2011 to July 2012 were collected and divided into the treatment group (n=33) and the control
group (n=31) according to methods of treatment. The patients in the two groups were both treated by normal fluid infu-
sion and symptomatic treatment, and those in the treatment group were additionally treated by Rlboflavin Sodium
Phosphate Injection simultaneously, once per day, 5~7 d via injection. The change in the time of herpes repressed, ap-
petite, temperature and side effects were analyzed. Results The time of herpes repressed, and the time of recovering
normal appetite and normal temperature in treatment group [(4.45±0.51) d, (3.11±0.1) d, (3.19±0.6) d, respectively]
was significantly shorter than those in the control group [(6.55±1.51) d, (4.09±0.8) d, (35.0±1.29) d, respectively], P<
0.05. The apparent effective rate (72.7%) and total effective rate (90.9%) in the treatment group were both significant-
ly higher than those in the control group (41.9%, 90.3%), P<0.05. There was no obvious side effects during treatment.
Conclusion There was apparent response using Rlboflavin Sodium Phosphate Injection for treating HFMD.

      【Key words】 Hand, foot and mouth disease (HFMD); Riboflavin sodium phosphate injection; Efficacy
·论 著·doi:10.3969/j.issn.1003-6350.2013.06.0353