标题：孕晚期低蛋白血症的原因及其对妊娠结局的影响

      作者：何雁红
    （佛山市顺德区桂洲医院妇产科，广东 佛山 528305）

      卷次： 2013年24卷6期

      【摘要】 目的 调查妊娠晚期孕妇低蛋白血症发生的原因及其对妊娠结局的影响。方法 选取2010-2011
年间来我院进行分娩的妊娠晚期孕妇90例，所有入选的孕妇均经过生化学检测确定为低蛋白血症，再根据病因
学的相关依据将其分为子痫前期组(48例)、非子痫前期组(42例)，并选取45例健康妊娠晚期孕妇进行对照。分析
导致妊娠晚期孕妇低蛋白血症发生的排在前3位的病因，并比较三组间的总蛋白、白蛋白、前白蛋白的含量及三
组间胎儿生长受限、胎盘早剥离、早产的发生状况。结果 妊娠晚期孕妇低蛋白血症发生的前三位的病因分别
为子痫前期(48例，53.33%)、肝脏疾病（14例，15.56%）、多胎妊娠(12例，13.33%)，同时三组间的总蛋白、白蛋白、
前白蛋白的含量差异有统计学意义(P<0.05)，子痫前期组胎儿生长受限率、胎盘早剥离率、早产率均显著高于非
子痫前期组和对照组。结论 妊娠晚期孕妇低蛋白血症发生的主要病因为子痫前期、肝脏疾病、多胎妊娠，且低
蛋白血症的发生会显著增加胎儿生长受限率、胎盘早剥离率、早产率。

      【关键词】 妊娠晚期；低蛋白血症；影响因素；妊娠结局

      【中图分类号】 R714.25 【文献标识码】 A 【文章编号】 1003—6350（2013）06—0822—02


Reasons of late pregnancy hypoproteinemia and its influences on pregnancy outcome.
HE Yan-hong. Department of
Gynaecology and Obstetrics, Guizhou Hospital of Shunde District of Foshan City, Foshan 528305, Guangdong, CHINA

【Abstract】 Objective To investigate the reasons of hypoproteinemia in late trimester of pregnancyand its in-
fluences on pregnancy outcome. Methods Ninety pregnant women in late trimester of pregnancy who have had de-
livery from 2010 to 2011 hadbeen diagnosed with hypoproteinemia after biochemical test. They were divided into pre-
eclampsia group (48 cases) and non preeclampsia group (42 cases) according to relevant nosetiology knowledge. For-
ty-five healthy pregnant women in late trimester of pregnancy were selected as the comtrol group. The top three
causes for hypoproteinemia were analyzed. The content of total protein, albumin and prealbumin, and happening situa-
tions of fetal growth restriction, placenta early stripping and premature delivery were compared between the three
groups. Results The top three causes for hypoproteinemia were preeclampsia (48 cases, 53.33%), hepatic disease
(14 cases, 15.56%) and multifetation (12 cases, 13.33%), and the differences between the three groups in content of to-
tal protein, albumin and prealbumin were statistically significant (P<0.05). Fetal growth restriction rate, placenta early
stripping rate and premature delivery rate in preeclampsia group were significantly higher than those in non preeclamp-
sia group and Control group. Conclusion Primary reasons for hypoproteinemia in late trimester of pregnancy are
preeclampsia, liver disease and multiple pregnancy, and hypoproteinemia would increase fetal growth restriction rate,
placenta early stripping rate and premature delivery rate significantly.

      【Key words】 Late trimester of pregnancy; Hypoproteinemia; Influencing fator; Pregnancy outcome