标题：海南地区不孕人群HBV感染对体外受精-胚胎移植结局的影响

      作者：周立花，符免艾，李娟
    (海南省农垦总医院生殖科，海南 海口 570311）

      卷次： 2016年27卷7期

      【摘要】 目的 了解海南地区不孕人群HBV的感染率，探讨男方或女方HBV感染对体外受精-胚胎移植
(IVF-ET)结局的影响。方法 回顾性分析2009年1月至2014年12月在我院生殖科行 IVF-ET助孕治疗的1 192对
夫妇共1 192个周期的资料，统计男性HBsAg(+)与女性HBsAg(+)例数，了解HBV的感染率。从1 192个周期中选
取男性HBsAg(+)女性HBsAg(-) 123个周期为男性HBV感染组、女性HBsAg(+)男性HBsAg(-) 83个周期为女性
HBV感染组，随机选择男女双方均HBsAg(-) 165个周期为对照组。分别比较男性HBV感染组、女性HBV感染组
与对照组的精子质量、受精率、优质胚胎率、种植率和临床妊娠率等各项指标之间的差异性。结果 1 192对夫妇个周
期中HBV感染率为15.98% (381/2 384)。男性HBV感染组与对照组比较精子质量差异无统计学意义(P>0.05)，2pn受
精率低于对照组(56.8% vs 60.8%)，但移植日子宫内膜厚度厚于对照组[(12.06±2.95) mm vs (11.06±2.29) mm]，临床妊
娠率高于对照组(41.5% vs 30.0%)，差异均有统计学意义(P<0.05)。女性HBV感染组与对照组相比两组的种植率
[24.2% (66/204) vs 30.1% (45/150)]、临床妊娠率 (37.5% vs 30.0%)等指标比较差异均无统计学意义 (P>0.05)。
结论 海南地区不孕人群HBV的感染率偏高，但无论是男方还是女方感染HBV均未影响 IVF助孕结局。

      【关键词】 海南地区；乙型肝炎；精子质量；体外受精-胚胎移植

      【中图分类号】 R512.6+2 【文献标识码】 A 【文章编号】 1003—6350（2016）07—1044—04


Impact of HBV infection on the outcomes of in vitro fertilization and embryo transfer in Hainnan province.
ZHOU
Li-hua, FU Mian-ai, LI Juan. Department of Reproduction, Hainan Provincial Nongken General Hospital, Haikou 570311,
Hainan, CHINA

【Abstract】 Objective To examine the prevalence of hepatitis B virus (HBV) infection in the infertile couples
in Hainan province, and to analyze the effect of HBV infection on the outcomes of in vitro fertilization and embryo trans-
fer (IVF-ET). Methods A retrospective analysis was performed on 1 192 couples receiving IVF-ET (1 192 cycles)
form January 2009 to December 2014 in Hainan Provincial Nongken General Hospital. The number of males and fe-
males with HBsAg(+) was recorded, and the prevalence of HBV infection was examined. One hundred and twenty-three
cycles of male HBsAg (+) and female HBsAg (-) were selected as male HBV infected group, and 83 cycles of female
HBsAg (+) and male HBsAg (-) were selected as female HBV infected group, with 165 cycles of male HBsAg (-) and
female HBsAg (-) as the control group. Sperm quality, fertilization rate, high-quality embryo rate, implantation rate, and
clinical pregnancy rate were compared between male HBV infected group and control group, female HBV infected
group and control group. Results The HBV infection rate was 15.98%(381/2 384) in the 1 192 couples. Male HBV in-
fected group and control group had no statistically significant difference in sperm quality (P>0.05), but the two groups
showed statistically significant difference in 2pn fertilization rate (56.8% vs 60.8%), endometrial thickness on the day of
·论 著·
6350.2016.07.005