标题：2011年住院患者革兰氏阳性球菌耐药监测分析

      作者：林健梅，杨兴祥，喻 华，乔 宁，黄湘宁，江 南
    （四川省人民医院感染科，四川 成都 610072）

      卷次： 2013年24卷5期

      【摘要】 目的 了解住院患者中革兰氏阳性球菌的分布及其对常用抗菌药物的耐药状况，为临床预防和控
制住院患者革兰氏阳性球菌感染提供参考。方法 对四川省人民医院2011年临床分离的1 927株革兰氏阳性球
菌采用Vitek全自动细菌鉴定仪及纸片扩散法(K-B法)进行细菌鉴定及药物敏感性分析。结果 1 927株革兰氏
阳性球菌中，以金黄色葡萄球菌为主，占42.35%，其次为表皮葡萄球菌，占28.75%，屎肠球菌、肺炎链球菌、溶血
葡萄球菌、粪肠球菌分别占12.51%、5.55%、5.45%及5.40%。金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌检出
率占66.85%。所有葡萄球菌对利奈唑胺及替加环素均敏感，金黄色葡萄球菌对万古霉素的敏感性为99.63%；粪
肠球菌对万古霉素及替加环素均敏感，对利奈唑胺不同程度耐药；屎肠球菌对利奈唑胺、万古霉素及替加环素均
有不同程度耐药；肺炎链球菌对万古霉素及替加环素均敏感。结论 葡萄球菌、肠球菌及肺炎链球菌耐药性需
加强监测，并采取有效控制措施。

      【关键词】 革兰阳性球菌；药敏试验；耐药监测

      【中图分类号】 R446.5 【文献标识码】 B 【文章编号】 1003—6350（2013）05—0732—03


Surveillance of drug resistance of Gram-positive coccus in the inpatients in 2011.
LIN Jian-mei, YANG
Xing-xiang, YU Hua, QIAO Ning, HUANG Xiang-ning, JIANG Nan. Department of Infection, Sichuan Provincial
People's Hospital, Chengdu 610072, Sichuan, CHINA

【Abstract】 Objective To investigate the distribution of Gram-positive coccus in inpatients and the drug in
Gram-positive coccus, in order to provide reference for managing Gram-positive Cocci infection. Methods A total
of 1 927 strains of Gram-positive Cocci isolated in Sichuan Provincial People's Hospital were identified with a Vitek 2
microbiology analyzer. Antimicrobial susceptibility testing was performed by First-Bauer disk diffusion. Results Of
the 1 927 strains, Staphylococcus aureus accounted for 42.35%, followed by staphylococcus epidermidis (28.75%), En-
terococcus faecium (12.51%), Streptococcus pneumoniato (5.55%), staphylococcus hemolyticus (5.45%) and Entero-
coccus faecalis (5.40%). Methicillin-resistant strains in Staphylococcus aureus accounted for 66.85%. All the Staphylo-
coccus strains were found sensitive to linezolid and tigecycline. The sensitivity rate of Staphylococcus aureus to vanco-
mycin was 99. 63%. Enterococcus faecalis was sensitive to vancomycin and tigecycline, but showed resistance to line-
zolid. Enterococcus faecalis was also found to be resistant to linezolid, vancomycin and tigecycline. Streptococcus pneu-
moniato was found sensitive to linezolid and tigecycline. Conclusion Surveillance of drug resistance of Staphylococ-
cus, Enterococcus and Streptococcus pneumoniato is very important, and effective control measures are necessary.

      【Key words】 Gram-positive coccus; Bacterial susceptibility testing; Surveillance of drug resistance
·药物与临床·