标题：灯盏花素与激素联合环磷酰胺治疗活动性狼疮性肾炎的疗效观察

      作者：周小强，赵小玲，黄联继，郭树清，陈岗梅
    （广东韶关学院医学院内儿科教研室，广东 韶关 512026）

      卷次： 2013年24卷5期

      【摘要】 目的 观察灯盏花素联合激素和环磷酰胺(CTX)治疗活动性狼疮性肾炎(LN)的临床疗效。
方法 将66例LN患者按随机原则分为两组各33例，对照组予常规激素及CTX治疗，治疗组在常规治疗基础上
加灯盏花素治疗。所有患者随访6个月，观察并比较两组LN患者临床疗效及服药后毒副作用等指标。结果 治
疗6个月后，治疗组总的治疗有效率明显高于对照组，两组比较差异有统计学意义(P<0.05)；治疗组患者尿蛋白及
尿RBC下降程度、抗核抗体转阴率及C3恢复正常率显著优于对照组(P<0.05)，与对照组比较其差异均具有统计
学意义(P<0.05)；治疗过程中，治疗组患者毒副作用的发生率低于对照组(P<0.05)。结论 灯盏花素联合激素和
环磷酰胺治疗活动性狼疮性肾炎不仅能提高疗效，还能显著降低西药的毒副作用。

      【关键词】 灯盏花素；糖皮质激素；环磷酰胺；活动性狼疮性肾炎

      【中图分类号】 R593.24+2 【文献标识码】 A 【文章编号】 1003—6350（2013）05—0650—03


Curative effect of breviscapine combined with glucocorticoid and cyclophosphamide in the treatment of active
lupus nephritis.
ZHOU Xiao-qiang, ZHAO Xiao-ling, HUANG Lian-ji, GUO Shu-qing, CHEN Gang-mei. Department
of Internal Paediatric Medicine, School of Medicine, Shaoguan University, Shaoguan 512026, Guangdong, CHINA

【Abstract】 Objective To observe the clinical efficacy of breviscapine combined with prednisone and cyclo-
phosphamide (CTX) in treatment of active lupus nephritis (LN). Methods Sixty-six patients of LN were randomly
divided into two groups, with 33 patients in each group. Patients in the control group were given conventional thera-
py of prednisone and cyclophosphamide (CTX), while those in the study group were given breviscapine combined
with prednisone and cyclophosphamide. The clinical efficacy and side effects were compared between the two
·论 著·doi:10.3969/j.issn.1003-6350.2013.05.0279