标题：穿心莲对湿热型消化性溃疡治疗作用的影响

      作者：邢明泉，李晓梅，刘 姣，白 芳，黄素霞，陈桂敏
    （海南医学院中医学院，海南 海口 571101）

      卷次： 2013年24卷5期

      【摘要】 目的 探讨单味清热燥湿中药穿心莲对消化性溃疡的治疗作用。方法 采用皮下注射消炎痛法
建立大鼠胃溃疡模型，将实验大鼠分为生理盐水对照组（生理盐水灌胃），低、中、高剂量穿心莲免煎颗粒剂治疗
组（低、中、高剂量穿心莲悬浊液灌胃）及西药治疗组（奥美拉唑悬浊液灌胃）五组，每天灌胃1次，连续30 d，观察
各组大鼠一般状况及溃疡指数变化。结果 穿心莲各组和西药组及模型组组相比较胃黏膜肉眼观和组织切片
上差异均有统计学意义；溃疡指数与模型组组比较，中药各组及西药组差异均有统计学意义(P<0.01)，与西药组
比较，中药低剂量及高剂量组差异有统计学意义(P<0.01)，与中药高剂量组比较，低剂量组差异有统计学意义
(P<0.01)，中药中剂量组差异有统计学意义（P<0.05）。结论 穿心莲对消炎痛所致的胃溃疡大鼠有治疗作用，证
明了清热解毒燥湿中药单味穿心莲可通过祛除湿热治疗胃溃疡。

      【关键词】 穿心莲；胃溃疡；湿热

      【中图分类号】 R-332 【文献标识码】 A 【文章编号】 1003—6350（2013）05—0639—03


Therapeutic effect of herbal Andrographis in the treatment of peptic ulcer due to damp-heat.
XING Ming-quan,
LI Xiao-mei, LIU Jiao, BAI Fang, HUANG Su-xia, CHEN Gui-min. School of Traditional Chinese Medicine, Hainan
Medical College, Haikou 571101, Hainan, CHINA

【Abstract】 Objective To investigate the effect of herbal Andrographis in the treatment of peptic ulcer due to
damp-heat. Methods Rat gastric ulcer models were established by hypodermic indomethacin and then divided into
five groups: saline control group (gavage of normal saline), low, medium and high dose Andrographis granules treat-
ment group (low, medium, the high dose Andrographis suspension), and western medicine treatment group (the
omeprazole suspension gavage). After consecutive 30 days of treatment, the general condition and ulcer index changes
of these rats were observed and compared. Results Significant differences in gastric mucosa were observed between
the three Andrographis granules treatment groups, saline control group, and western medicine treatment group both un-
der microscope and naked eyes. Ulcer indexes of the Andrographis granules treatment groups were also significantly
different from the control group and western medicine treatment group. Among the low, medium, the high dose An-
drographis treatment group, significant difference were also observed (P<0.01). Conclusion Andrographis shows
good therapeutic effects on indomethacin-induced gastric ulcers, whch indicates single herb of Andrographis can elimi-
nate damp-heat by clearing away heat and resolving toxicity.