标题：帕瑞昔布钠超前镇痛在胸腔镜肺大疱切除术中的应用

      作者：伍堂洪
    （东莞市太平人民医院麻醉科，广东 东莞 523900）

      卷次： 2013年24卷4期

      【摘要】 目的 探讨帕瑞昔布钠超前镇痛对胸腔镜肺大疱切除术后疼痛的影响。方法 130例双腔气管插
管全麻下行肺大疱切除术患者，按随机数字表法分为对照组和观察组各65例，观察组患者于术前15 min静脉注
射40 mg帕瑞昔布钠，而对照组患者则静脉注射2 ml生理盐水。采用视觉模拟评分法(VAS)分别于术后1 h、2 h、
4 h、8 h和12 h评估患者疼痛程度，记录患者恶心呕吐、呼吸抑制、皮肤瘙痒和尿潴留等不良反应。结果 与对照
组患者比较，观察组各个时段VAS评分明显降低(P<0.05)，观察组镇痛的满意率明显升高 (P<0.05)，观察组患者
在恶心呕吐、皮肤瘙痒及尿潴留的发生率差异无统计学意义(P>0.05)。结论 胸腔镜肺大疱切除术患者手术前
静注帕瑞昔布钠超前镇痛效果确切，满意度高，无增加恶心呕吐、皮肤瘙痒及尿潴留副作用。

      【关键词】 帕瑞昔布钠；超前镇痛；胸腔镜；肺大疱切除术；疼痛

      【中图分类号】 R655 【文献标识码】 A 【文章编号】 1003—6350（2013）04—0510—02


Application of parecoxib sodium for preemptive analgesia in patients undergoing thoracoscopic bullectomy.
WU
Tang-hong. Department of Anesthesiology, Dongguan Taiping People's Hospital, Dongguan 523900, Guangdong, CHINA

【Abstract】 Objective To investigate the preemptive analgesia effect of parecoxib sodium after thoracoscop-
ic bullectomy. Methods One hundred and thirty patients undergoing thoracoscopic bullectomy under double-lumen
endotracheal intubation were divided into the control group and the observation group, according to random number ta-
ble. The observation group (n=65) were given 40 mg parecoxib sodium intravenously 15 min before operation, while
patients in the control group (n=65) were given 2 ml normal saline intravenously. Visual analogue scale (VAS) were
applied to assess the degree of pain in patients 1 h, 2 h, 4 h, 8 h and 12 h after operation. Adverse reactions were re-
corded, including nausea and vomiting, respiratory depression, itchy skin, and urinary retention. Results Compared
with the control group, the observation group had significantly lower VAS scores (P<0.05) and significantly higher an-
algesia satisfaction rate (P<0.05). The two groups showed no statistically significant difference in the incidence of nau-
sea and vomiting, itchy skin and urinary retention (P>0.05). Conclusion Application of parecoxib sodium before tho-
racoscopic bullectomy shows good preemptive analgesia effect, which results in greater patient satisfaction and no
higher incidence of adverse reactions such as nausea and vomiting, itchy skin and urinary retention.

      【Key words】 Parecoxib sodium; Preemptive analgesia; Thoracoscope; Bullectomy; Pain