标题:慢性阻塞性肺疾病患者的血清瘦素、血清脂联素水平及其影响因素分析
作者:张 鸿,兰映霞,龚鸿裕,杨志伟,张文武
(深圳市宝安区人民医院急诊科,广东 深圳 518101)
卷次:
2013年24卷3期
【摘要】 目的 分析慢性阻塞性肺疾病(COPD)患者血清瘦素和脂联素水平及其影响因素。方法 用放射免
疫法(RIA)和酶联免疫吸附法(ELISA)检测90例COPD患者(COPD组)和22例健康对照者(健康组)血清脂联素、瘦素
水平。结果 COPD组血清脂联素、瘦素水平与健康组比较,差异有统计学意义(均为P<0.05),且COPD营养不良
组、COPD营养正常组、健康组的瘦素、脂联素水平、FEV1%、FVC%、FEV1/FVC比较,差异有统计学意义(P<0.05)。
结论 COPD患者血清脂联素和瘦素水平的下降与COPD的炎症反应、营养状况及病情的发展密切相关。
【关键词】 慢性阻塞性肺疾病;瘦素;脂联素
【中图分类号】 R563 【文献标识码】 A 【文章编号】 1003—6350(2013)03—0386—02
Serum leptin and adiponectin levels in patients with chronic obstructive pulmonary disease and their
influencing factors.
ZHANG Hong, LAN Ying-xia, GONG Hong-yu, YANG Zhi-wei, ZHANG Wen-wu. Emergency
Department, People's Hospital of Bao'an District of Shenzhen City, Shenzhen 518101, Guangdong, CHINA
【Abstract】 Objective To analyze the serum adiponectin and leptin levels in patients with chronic obstruc-
tive pulmonary disease (COPD) and their influencing factors. Methods The serum adiponectin and leptin levels in
90 COPD patients (COPD group) and 22 healthy individuals (the control group) were measured by radio-immunity
method and enzyme-linked immunosorbent assay. Results Serum adiponectin and leptin levels showed significantly
significant difference between the COPD group than the control group (P<0.05). The FEV1/FVC, FVC%, FEV1%, and
serum adiponectin and leptin levels showed statistically significant difference between the COPD group with malnutri-
tion, the COPD group with normal nutrition, and the control group. Conclusion The decrease of the serum adiponectin
and leptin levels in COPD patients is associated with the disease progress, nutritional status and inflammatory response.
【Key words】 Chronic obstructive pulmonary disease; Leptin; Adiponectin
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