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      标题:三维适形放疗联合化疗治疗食管癌术后纵隔淋巴结转移的临床疗效观察
      作者:赵登平,张社军,李民华
    (磁县肿瘤医院放疗科,河北 磁县 056500)
      卷次: 2013年24卷4期
      【摘要】 目的 探讨三维适形放疗联合化疗对食管癌术后纵隔淋巴结转移的综合疗效。方法 选取2009
年11月至2011年11月于本院采用常规放疗联合化疗进行治疗的33例食管癌术后纵隔淋巴结转移患者为对照
组,同期采用三维适形放疗联合化疗进行治疗的33例患者为观察组,将两组患者的治疗总有效率、不良反应发生
率及治疗前后的血清肿瘤标志物、肿瘤转移相关因子进行检测及比较。结果 观察组的治疗总有效率为
93.94%,高于对照组的 78.79%,放射性气管炎、胃肠道反应及其他不良反应发生率分别为 21.21%、12.12%和
6.06%,均低于对照组的 33.33%、24.24%和 21.21%,血清肿瘤标志物和肿瘤转移相关因子改善幅度均大于对照
组,差异有统计学意义(P<0.05)。结论 三维适形放疗联合化疗对食管癌术后纵隔淋巴结转移的综合疗效较
佳,安全性也较高。

      【关键词】 三维适形放疗;化疗;食管癌; 纵隔淋巴结转移;综合疗效

      【中图分类号】 R735.1 【文献标识码】 A 【文章编号】 1003—6350(2013)04—0486—03

Clinial observation on the effect of three-dimensional conformal radiotherapy combined with chemotherapy in
the treatment of mediastinal lymph node metastasis after esophageal cancer sugery. ZHAO Deng-ping, ZHANG
She-jun, LI Min-hua. Depatment of Radiotherapy, Cancer Hospital of Cixian, Ci Cixian 056500, Hebei, CHINA

      【Abstract】 Objective To study the comprehensive effect of three-dimensional conformal radiotherapy com-
bined with chemotherapy in the treatment of mediastinal lymph node metastasis in patients with esophageal cancer af-
ter surgery. Methods Thirty patients of esophageal cancer with mediastinal lymph node metastasis after surgery who
were treated with conventional radiotherapy combined with chemotherapy from November 2009 to November 2011
were selected as the control group, and 33 patients who were treated with three-dimensional conformal radiotherapy
combined with chemotherapy at the same time were selected as the sutdy group. The total effective rate, the incidence
of adverse reactions, serum tumor markers, tumor metastasis related factors before and after the treatment of the two
groups were detected and compared. Results The total effective rate of the study group was 93.94%, significantly
higher than 78.79% in the control group, The incidence of radioactive tracheitis, gastrointestinal reaction and other ad-
verse reactions were 21.21%, 12.12% and 6.06% in the study group, significantly lower than those in the control group
(33.33%, 24.24% and 21.21%). The improvement range of serum tumor markers and tumor metastasis related factors
were all significantly larger in the study group than the control group (P<0.05). Conclusion For treating mediastinal
lymph node metastasis after esophageal cancer surgery, three-dimensional conformal radiotherapy combined with chemo-
therapy is more effective and safer, compared with conventional radiotherapy combined with chemotherapy.

      【Key words】 Three-dimensional conformal radiotherapy; Chemotherapy; Esophageal cancer; Mediastinal
lymph node metastasis; Comprehensive effect

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