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      标题:早期系统营养干预对鼻咽癌患者放化疗毒副反应的影响
      作者:曾满萍,侯英兰,陈庆丽
    (郴州市第一人民医院南院,湖南 郴州 423000)
      卷次: 2013年24卷4期
      【摘要】 目的 探讨早期、系统营养干预对鼻咽癌患者放化疗毒副反应的影响。方法 将80例鼻咽癌初治
患者随机分为干预组(放化疗+系统营养干预)和对照组(单纯放化疗),各40例,观察系统营养干预对鼻咽癌患者
营养状况、口咽黏膜反应、骨髓抑制等毒副反应的影响。结果 干预组和对照组均出现不同程度的MNA评分下
降及口咽黏膜放射性损伤、骨髓抑制等毒副反应,但指标下降的程度及放射性损伤的分级,营养组明显轻于对照
组,差异有统计学意义(P<0.05)。结论 早期、系统营养干预可有效地改善鼻咽癌患者的营养状况,减轻其毒副
反应,提高放化疗耐受性。

      【关键词】 营养干预;鼻咽癌;毒副反应;放疗;化疗

      【中图分类号】 R739.63 【文献标识码】 A 【文章编号】 1003—6350(2013)04—0480—03

Effect of early nutritional intervention on the adverse reactions of radiotherapy and chemotherapy in patients
with nasopharyngeal carcinoma. ZENG Man-ping, HOU Ying-lan, CHEN Qin-li. The First People's Hospital of
Chenzhou City, Chenzhou 423000, Hunan, CHINA

      【Abstract】 Objective To investigate the early nutritional in tervention on the adverse reactions of radiotherapy
and chemotherapy in patients with nasopharyngeal carcinoma (NPC). Methods Eighty NPC patients were randomly di-
vided into the intervention group (n=40, treated with radiotherapy and chemotherapy combined with nutritional interven-
tion) and the control group (n=40, treated with radiotherapy and chemotherapy). The effect of nutritional intervention on
nutritional status, the reaction of oropharyngeal mucosa, and bone marrow suppression were observed. Results Both the
two groups were observed with MNA score decreasing, oropharyngeal mucosal injury, bone marrow suppression. But the
decline degree of the indexes and the injury classification was significantly lighter in the intervention group than the control
group (P<0.05). Conclusion Early nutritional intervention can effectively improve the nutritional status of the patients
with nasopharyngeal carcinoma, reduce the adverse reactions, and improve the tolerance of radiotherapy and chemotherapy.

      【Key words】 Nutritional intervention; Nasopharyngeal carcinoma; Adverse reactions; Radiotherapy; Chemotherapy
·论 著·doi:10.3969/j.issn.1003-6350.2013.04.0209

      基金项目:湖南省郴州市科技局科研项目资助(编号:2011-4)

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