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      标题:GSTM1基因多态性与海南中老年胃癌易感性的关联性研究
      作者:王文文 1,杨文明 2,张云霞 3
    (1.海南省人民医院消化内科,海南 海口 571100;
2.海南医学院生物技术班,海南 海口 571100;
3.海南医学院理学院,海南 海口 571100)
      卷次: 2013年24卷4期
      【摘要】 目的 初步研究生物转化酶类谷胱甘肽转硫酶M1(GSMT1)基因缺失多态性与海南中老年人群胃
癌易感性的关系。方法 收集我院中老年胃癌患者血液DNA 130例作为实验组,体检科中老年健康体检者血液
DNA 138例作为对照组,利用PCR技术对所有的DNA样本进行GSTM1缺失多态性的检测。结果 GSTM1(-)/
GSTM1(+)在实验组中的检出率为29.8%/70.2%,在对照组中的检出率为18.8%/81.2%,两组间的数据经统计学分
析差异具有统计学意义(χ2=4.538,P=0.033<0.05)。结论 GSTM1基因缺失多态性与海南中老年人群胃癌易感
性有关,GSTM1(-)可能是海南中老年胃癌患者的易感基因型。

      【关键词】 胃癌;中老年;谷胱甘肽转硫酶

      【中图分类号】 R735.2 【文献标识码】 A 【文章编号】 1003—6350(2013)04—0474—02

Correlation between GSTM1 gene polymorphism and the susceptibility to gastric cancer in the middle-aged
and elderly in Hainan province. WANG Wen-wen 1, YANG Wen-ming 2, ZHANG Yun-xia 3. 1. Department of
Gastroenterology, People's Hospital of Hainan Province, Haikou 571100, Hainan, CHINA; 2. Biotechnology Class, Hainan
Medical University, Haikou 571100, Hainan, CHINA; 3. College of Science, Hainan Medical College, Haikou 571100,
Hainan, CHINA

      【Abstract】 Objective To investigate the correlation between the polymorphism of glutathione
S-transferase M1 (GSTM1) gene and the susceptibility to gastric cancer in the middle-aged and elderly in
Hainan province. Methods DNA samples were collected in 130 middle-aged and elderly patients (the study group)
with gastric cancer and 138 healthy middle-aged and elderly people (the control group). The GSTM1(-)/GSTM1(+)
polymorphism were detected by PCR. Results The frequency of GSTM1(-)/GSTM1(+ ) was 29.8%/70.2% in the
study group and 18.8%/81.2% in the control group, with statistically significant difference between the two
groups (χ 2=4.538, P=0.033<0.05). Conclusion The deletion polymorphism of GSTM1 is related to the suscepti-
bility to gastric cancer in the middle-aged and elderly. GSTM1(-) might be the genotype for susceptibility.

      【Key words】 Gastric cancer; Middle-aged and elderly; Glutathione S-transferase (GST)

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