标题：替罗非班对急性心肌梗死患者经皮冠状动脉介入治疗术后支架内血栓形成的影响

      作者：冯军鹏，王有恒，梁梅芳
    （铜川市人民医院心血管内科，陕西 铜川 727000）

      卷次： 2013年24卷2期

      【摘要】 目的 探讨急性心肌梗死患者经皮冠状动脉介入治疗后联用替罗非班对术后支架内血栓形成的
影响。方法 选取我院2010年1月至2011年1月收治的接受冠状动脉介入治疗的60例急性心肌梗死患者，将其
随机分成实验组和对照组，实验组30例，采用冠状动脉介入治疗联用替罗非班的方案；对照组30例，采用直接介
入治疗。分别观察两组患者经不同治疗方式后的临床表现。结果 实验组患者术后支架内血栓形成例数少于
对照组患者（P<0.05），且术后死亡例数较对照组患者减少（P<0.05），差异均具有统计学意义。结论 替罗非班对
减少急性心肌梗死患者术后支架内血栓的形成具有良好的作用，值得临床上广泛应用。

      【关键词】 急性心肌梗死；经皮冠状动脉介入治疗；替罗非班；血栓

      【中图分类号】 R542.2+2 【文献标识码】 A 【文章编号】 1003—6350（2013）02—0174—02


Effect of tirofiban on stent thrombosis in patients of acute myocardial infarction after percutaneous coronary
intervention.
FENG Jun-peng, WANG You-heng, LIANG Mei-fang. Cardiovascular department, People's Hospital of
Tongchuan City, Tongchuan 727000, Shaanxi, CHINA

【Abstract】 Objective To explore the effect of tirofiban on stent thrombosis in patients of acute myocardial infarc-
tion after percutaneous coronary intervention. Methods Sixty patients of acute myocardial infarction undergoing percuta-
neous coronary intervention in our hospital from January 2010 to January 2011 were randomly divided into two groups: the
study group and the control group. Patients in the study group (n=30) were treated with percutaneous coronary intervention
combined with tirofiban. Patients in the control group (n=30) were treated with percutaneous coronary intervention. The
clinical manifestations were observed and compared between the two groups. Results Compared with the con-
trol group, the study goup had signigicantly less cases of stent thrombosis and significantly less cases of postoper-
ative death (P<0.05), with statistically significant differece. Conclusion Tirofiban has a positive impact on reducing
the formation of coronary stent thrombosis, which is worth to be widely used in clinical application.

      【Key words】 Acute myocardial infarction; Percutaneous coronary intervention; Tirofiban, Thrombosis