标题：肺表面活性物质治疗早产儿呼吸窘迫综合征临床疗效分析

      作者：刘红霞，李小玲，刘仁红，肖 毅
    （广州医学院附属深圳沙井医院儿科，广东 深圳 518104）

      卷次： 2012年23卷24期

      【摘要】 目的 探讨肺表面活性物质治疗早产儿呼吸窘迫综合征的临床应用价值。方法 选择早产儿呼吸窘迫
综合征患儿83例，根据随机的方法分为观察组和对照组。对照组患儿应用常规治疗，观察组患儿在此基础上应用猪肺
磷脂注射液。检测并比较两组患儿治疗前、治疗12 h、24 h的PaO2、PaCO2及PaO2/FiO2水平；比较两组间平均机械通气
时间、氧疗时间、住院时间及并发症发生情况。结果 ①治疗后12 h及24 h，观察组患儿PaO2、PaCO2及PaO2/FiO2水平
改善情况均优于对照组，差异均有统计学意义（P<0.05）。②观察组患儿机械通气时间、氧疗时间及住院时间均显著短于
对照组患儿，差异均有统计学意义（P<0.05）。③观察组患儿感染、颅内出血、呼吸暂停、肺气漏及死亡的发生率均显著低
于对照组，差异均有统计学意义（P<0.05）。结论 肺表面活性物质治疗早产儿呼吸窘迫综合征疗效显著。

      【关键词】 肺表面活性物质；早产儿；呼吸窘迫综合征；治疗

      【中图分类号】 R722.1 【文献标识码】 A 【文章编号】 1003—6350（2012）24—046—03<

br>Clinical efficacy of pulmonary surfactant in the treatment of premature infants with respiratory distress
syndrome.
LIU Hong-xia, LI Xiao-ling, LIU Ren-hong, XIAO Yi. Department of Pediatrics, Shenzhen Shajing Hospital
Affiliated to Guangzhou Medical University, Shenzhen 518104, Guangdong, CHINA

【Abstract】 Objective To investigate the clinical effect of pulmonary surfactant in the treatment of premature
infants with respiratory distress syndrome. Methods Eighty-three premature infants with respiratory distress syn-
drome were randomly divided into two groups. The control group was treated with conventional treatment, and the ob-
servation group was treated with lung phospholipids on the basis of conventional treatment. The levels of PaO2, Pa-
CO2 and PaO2/FiO2 before treatment, 12 h and 24 h after treatment were detected and compared between the two
groups. The average duration of mechanical ventilation and oxygen therapy, the length of hospital stay as well as the
incidence of complications were compared between the two groups. Results 12 h and 24 h after treatment, the im-
provements in the levels of PaO2, PaCO2 and PaO2/FiO2 were significantly better in the observation group than the con-
trol group (P<0.05). The duration of mechanical ventilation and oxygen therapy, as well as the length of hospital stay
in the observation group were significantly shorter than those in the control group (P<0.05). The incidence of infec-
tion, intracranial hemorrhage, apnea, pulmonary air leak and the death rate in the observation group were significantly
lower than those in the control group (P<0.05). Conclusion Pulmonary surfactant has good effect in the treatment of
premature infants with respiratory distress syndrome.

      【Key words】 Pulmonary surfactant; Premature children; Respiratory distress syndrome; Treatment
·临床研究·doi:10.3969/j.issn.1003-6350.2012.24.019