标题:f/tPSA、PSAD在PSA灰区对前列腺增生症和前列腺癌诊断效用的研究
作者:孙 鹏 1,包卫东 1,杨莉莉 2,沈 俭 1,顾燕青 1,沈 伟 1,沈 杰 1,俞奇伟 1,陈建华 1,3*
(1.上海交通大学医学院附属新华医院崇明分院泌尿外科,上海 202150;
2.蚌埠医学院临床1系2007级4班,安徽 蚌埠 233030;
3.上海交通大学医学院附属新华医院泌尿外科,上海 200092)
卷次:
2012年23卷24期
【摘要】 目的 探讨在PSA灰区(tPSA 4-10ng/ml)前列腺特异性抗原(PSA)、游离前列腺特异性抗原/总前
列腺特异性抗原(f/tPSA)、前列腺特异性抗原密度(PSAD)对前列腺增生症(BPH)、前列腺癌(PCa)的诊断效
用。方法 162例患者经临床确诊后分为BPH组 104例和PCa组 58例,分别检测其血清PSA、f/tPSA、直肠超声
检测前列腺体积并测算 PSAD数值。 结果 PCa组血清 tPSA与 BPH组之间差异无统计学意义(P>0.05)。
PCa组血清 f/tPSA较BPH组明显降低(P<0.01),PCa组 PSAD值较BPH组明显升高(P<0.01)。随 f/tPSA、PSAD
升高,PCa诊断的敏感度也升高但特异度下降。PSAD对PCa诊断特异度明显高于 f/tPSA比值。结论 f/tPSA
比值和PSAD对诊断BPH、PCa具有重要意义。
【关键词】 前列腺特异性抗原(PSA);前列腺特异性抗原密度(PSAD);前列腺增生症(BPH);前列腺癌(PCa)
【中图分类号】 R737.25 【文献标识码】 A 【文章编号】 1003—6350(2012)24—04—03r>Value of f/tPSAD and PSAD in PSA gray zone in the diagnosis of benign prostatic hyperplasia and prostatic cancer.
SUN Peng 1, BAO Wei-dong 1, YANG Li-li 2, SHEN Jian 1, GU Yan-qing 1, SHEN Wei 1, SHEN Jie 1, YU Qi-wei 1, CHEN
Jian-hua 1,3*.
1. Department of Urology, Chongming branch of Xin Hua Hospital Affiliated to Shanghai Jiao Tong
University, Shanghai 202150, CHINA; 2.Class 4, Grade 2007, NO.1 Department of Clinical Medicine of Bengbu Medical
College, Bengbu, 233030, Anhui, CHINA; 3. Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong
University, Shanghai 200092, CHINA
【Abstract】 Objective To investigate the diagnostic significance of f/tPSA, PSAD in PSA gray zone (tPSA 4~
10 ng/ml) for benign prostatic hyperplasia (BPH); and prostatic cancer (PCa). Methods One hundred and sixty-two
patients with BPH or PCa were divided into BPH group (n=104) and PCa group (n=58). The serum PSA, f/tPSA were de-
tected. Prostate volume and PSAD were calculated. Results The serum tPSA showed no statistically significant differ-
ence between the two groups (P>0.05). The serum f/tPSA in PCa group was significantly lower than that of BPH group (P<
0.01). PSAD in PCa group is prominently higher than that BPH group (P<0.01).With f/tPSA, PSAD increased, the diagnos-
tic sensitivity of PCa is increased, while specificity decreased. The diagnostic specificity of PSAD for PCa is significantly
higher than that of f/tPSA. Conclusion PSAD is more suitable for differentiating BPH and PCa than f/tPSA.
【Key words】 Prostate specific antigen (PSA); Prostate specific antigen density (PSAD); Benign prostatic hy-
perplasia (BPH); Prostatic cancer (PCa)
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