标题：慢性阻塞性肺病急性加重期CRP、CK-MB、LDH水平变化的临床意义

作者：陆霓虹，杨蕤，杨继群
（昆明市第三人民医院呼吸内科，云南昆明 650041）

卷次： 2012年23卷20期

      【摘要】目的 探讨血清C-反应蛋白（CRP）、磷酸肌酸激酶同工酶（CK-MB）和乳酸脱氢酶（LDH）在慢性
阻塞性肺病（COPD）急性加重期浓度变化及相关临床意义。方法 测定60例COPD患者急性加重期血清CRP、
CK-MB和LDH水平和动脉血氧分压(PaO2)，45例健康体检者血清CRP、CK-MB和LDH水平。结果 急性期
COPD患者血清CRP、CK-MB和LDH水平与健康体检者比较差异均有统计学意义（P<0.05）。相关性分析结果
显示，COPD急性期患者CRP与CK-MB、LDH之间及CK-MB与LDH之间呈正相关（P<0.05），COPD急性期患者
PaO2与CRP、CK-MB、LDH之间呈负相关（P<0.01）。结论 COPD急性加重期血清CRP浓度高，机体存在血氧饱
和度低、心肌功能异常及严重感染；联合检测CRP、CK-MB和LDH浓度可以为COPD的病情评估、治疗及预后提
供相关的评价指标。

      【关键词】 慢性阻塞性肺病；C-反应蛋白；磷酸肌酸激酶同工酶；乳酸脱氢酶

      【中图分类号】 R563 【文献标识码】 B 【文章编号】 1003—6350（2012）20—104—02<

br>Changes of serum CRP, CK-MB and LDH levels in patients with chronic obstructive pulmonary disease at
acute exacerbation and their clinical significance LU Ni-hong, YANG Rui, YANG Ji-qun.
Department of Respiratory
Medicine, The Third People's Hospital of Kunming City, Kunming 650041, Yunnan, CHINA

【Abstract】 Objective To investigate the changes in the serum levels of C-reactive protein (CRP), creatine ki-
nase MB isoenzyme (CK-MB) and lactate dehydrogenase (LDH) in patients with chronic obstructive pulmonary dis-
ease (COPD) at acute exacerbation, and to analyze their clinical significance. Methods The serum levels of CRP,
CK-MB, LDH and PaO2 were measured in 60 patients with COPD at acute exacerbation (the study group) and 45
healthy subjects (the control group). Results The serum levels of CRP, CK-MB, and LDH in the study group were
significantly higher than those in the control group (P<0.05). In the study group, positive correlation was found be-
tween CRP and CK-MB, LDH, as well as between CK-MB and LDH (P<0.01), while negative correlation was found
between PaO2 and CRP, CK-MB, LDH (P<0.01). Conclusion Combined detection of serum CRP, CK-MB and LDH
can provide reliable indicators for the diagnosis, prevention and treatment of COPD.

      【Key words】 Chronic obstructive pulmonary disease; C-reactive protein (CRP); Creatine kinase MB isoen-
zyme (CK-MB); Lactate dehydrogenase (LDH)

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