标题：Narcotrend与Ramsay在机械通气患者镇静中的相关性研究

      作者：吴文娟，张银英
    （中山市人民医院外科监护室，广东 中山 528403）

      卷次： 2012年23卷20期

      【摘要】 目的 探讨Narcotrend麻醉/脑电意识深度监测系统在丙泊酚靶控输注（TCI）下对 ICU机械通气患
者镇静深度数字化监测的可行性。方法 选取20例 ICU呼吸机机械通气同时进行丙泊酚靶控输注镇静患者，应
用Narcotrend进行监测。靶控浓度（Ct）从 0.5 ug/ml开始递增，达到满意镇静深度为止，观察NTI、Ramsay评分。
结果 丙泊酚滴定法靶控输注镇静时NTI随着Ct递增而递减，Ramsay评分随着Ct递增而递增，NTI与Ramsay
呈负相关，相关系数 r为-0.887；NTI与Ct呈负相关，相关系数 r为-0.756；Ramsay评分与Ct呈正相关，相关系数 r
为0.735（P<0.01）。结论 Narcotrend在机械通气患者丙泊酚TCI镇静深度评估中具有较好的相关性和可控性，
可以对丙泊酚TCI镇静实现数字化监测。

      【关键词】 Narcotrend；Ramsay；靶控输注；镇静；ICU

      【中图分类号】 R605.97 【文献标识码】 A 【文章编号】 1003—6350（2012）20—096—03<

br>Correlation analysis of Narcotrend index and Ramsay during TCI of propofol in patients with mechanical
ventilation.
WU Wen-juan, ZHANG Yin-ying. Department of Intensive Care Unit, People's Hospital of Zhongshan City,
Zhongshan 528403, Guangdong, CHINA

【Abstract】 Objective To investigate the feasibility of using Narcotrend for digital monitoring the TCI of
propofol for patients with mechanical ventilation in ICU. Methods Twenty patients with mechanical ventilation in
ICU were enrolled in this study. Propofol was administered by Grasby 3500 TCI system. The target concentration (Ct)
of propofol was increased step by step with 0.5 μ g/ml as the initial concentration until satisfactory sedation was
achieved. The Narcotrend index was recorded and Ramsay sedation score was measured each time we changed Ct of
15 minutes. Results Narcotrend index decreased and Ramsay increased as the target effect-site concentration (Ct) of
propofol increased step by step. There was a significant correlation between Narcotrend index and Ramsay, Narco-
trend index and Ct, Ramsay and Ct (P<0.01). Conclusion Narcotrend may be used for digital monitoring the TCI of
propofol in patients with mechanical ventilation in ICU.

      【Key words】 Narcotrend index (NTI); Ramsay; Target controlled infusion (TCI); Sedation; ICU