标题：早期应用尼莫地平对高血压性脑室出血患者中枢性发热的干预作用

      作者：黄志研
    （东莞市凤岗人民医院外二科，广东 东莞 523690）

      卷次： 2012年23卷20期

      【摘要】 目的 探讨早期应用尼莫地平对高血压性脑室出血患者中枢性发热的干预作用。方法 选择我
科2008年2月至2010年7月收治的经确诊为高血压性脑室出血的病例46例，并随机分为实验组（实施尼莫地平
治疗）及对照组（不实施尼莫地平治疗）各23例，随访1个月后，比较两组患者并发中枢性发热病例的分布差异。
结果 随访1个月，无中途退出病例，其中，实验组并发中枢性发热13例（高热3例，中低热10例），无死亡病例；
对照组并发中枢性发热15例（高热10例，中低热5例），死亡1例。两组患者中枢性发热病例的分布差异无统计
学意义（χ2=0.807，P=0.369>0.05），而中枢性高热病例的分布差异则具有统计学意义（χ2=3.939，P=0.047<0.05）。
结论 早期应用尼莫地平可降低高血压性脑室出血并发中枢性发热患者的发热程度，可能对于改善该类患者的
预后具有肯定意义。

      【关键词】 尼莫地平；中枢性发热；高血压性脑室出血；预后

      【中图分类号】 R743.34 【文献标识码】 A 【文章编号】 1003—6350（2012）20—046—03<

br>Intervention effect of nimodipine in the treatment of patients both with hypertensive ventricular hemorrhage
and central fever in early stage.
HUANG Zhi-yan. The Second Department of Surgery, Fenggang People's Hospital of
Dongguan City, Dongguan 523690, Guangdong, CHINA

【Abstract】 Objective To explore the effect of nimodipine on treating patients both with hypertensive ventric-
ular hemorrhage and central fever in the early stage. Methods Forty-six patients with hypertensive ventricular hem-
orrhage from Feb.2008 to Jul. 2010 were selected and randomly divided into experimental group (23 cases, treated
with nimodipine) and controlled group (23 cases, treated with nimodipine). Distribution of patients with central fever
was compared in both groups after following up for 1 month. Results After following up for 1 month, 13 patients
were found with central fever and 3 with hyperpyrexia, 10 with mild-moderate fever in the experimental group, but in
the controlled group, 15 patients were found with central fever and 10 with hyperpyrexia, 5 with mild-moderate fever.
There was no dead case in the experimental group but 1 case in the controlled group. The distribution of patients with
central fever in both groups has no statistical significance (χ2=0.807, P=0.369), but when compared with the distribu-
tion of patients with central high fever, statistical significance was found in the two groups (χ2=3.939, P=0.047), and
the controlled group seemed to have less patients with central high fever. Conclusion Nimodipine can reduce the lev-
el of fever for patients both with hypertensive ventricular hemorrhage and central fever in the early stage，which may
do good for the prognosis.

      【Key words】 Nimodipine；Central fever; Hypertensive ventricular hemorrhage; Prognosis