标题：VEGF、CD44v6、MMP-2在食管癌中的表达及其与淋巴结转移的相关性

      作者：洪英财，陈怀生，林少霖
    (暨南大学第二临床医学院/深圳市人民医院胸外科，广东 深圳 518000)

      卷次： 2016年27卷6期

      【摘要】 目的 研究食管癌患者的癌组织发生淋巴结转移与病变组织中血管内皮生长因子(VEGF)、细胞的粘
附因子C4D4的变异体v6 (CD44v6)、基质金属蛋白酶-2 (MMP-2)水平的关系。方法 选取2011年3月至2014年9
月到我院肿瘤科进行治疗的83例食管癌患者作为食管癌组，所有患者均经术后HE切片病理检查证实，另选取21
例术前诊断为食管癌但术后经组织学检查结果为良性者的食管黏膜标本作为良性组，比较两组患者中VEGF、
CD44v6和MMP-2的阳性水平，并对不同表达食管癌患者的淋巴结是否发生转移进行分析，探讨他们的相关性。
结果 VEGF、CD44v6和MMP-2在食管癌组患者病变组织标本中的阳性表达率分别为 77.11% (64/83)、73.49%
(61/83)和 59.04% (49/83)，而在良性组患者食管组织标本中的阳性表达率分别为 14.29% (3/21)、23.81% (5/21)和
14.29% (3/21)，三者在食管癌组患者病变组织标本中的阳性表达率均显著高于良性组，经比较差异均有统计学意义
(P<0.05)；VEGF、CD44v6和MMP-2在发生了淋巴结转移的食管癌患者中的阳性率依次为85.48% (53/62)、82.26%
(51/62)和 66.13% (41/62)，而在没有发生淋巴结转移的患者中的阳性率依次为 52.38% (11/21)、47.62% (10/21)和
38.10% (8/21)，发生淋巴结转移的食管癌患者病变组织标本中三者的阳性表达率显著高于没有发生转移者，经比较
差异均具有统计学意义(P<0.05)。结论 VEGF、CD44v6和MMP-2在食管癌患者癌变组织中的表达水平与其淋巴
结是否发生转移具有一定的关系，其对食管癌患者的早期正确诊断、治疗以及预后效果评估具有重要的意义。

      【关键词】 淋巴结转移；食管癌；血管内皮生长因子；细胞的粘附因子C4D4的变异体v6；基质金属蛋白酶-2

      【中图分类号】 R735.1 【文献标识码】 A 【文章编号】 1003—6350（2016）06—0888—04


Expression of VEGF, CD44v6, MMP-2 in esophageal cancer and the relationship with lymph node metastasis.
HONG Ying-cai, CHEN Huai-sheng, LIN Shao-lin.
Department of Thoracic Surgery, the Second Clinical Medical College of
Jinan University, People's Hospital of Shenzhen, Shenzhen 518000, Guangdong, CHINA

【Abstract】 Objective To study the correlation between vascular endothelial growth factor (VEGF), CD44 vari-
ant 6 (CD44v6), matrix metalloproteinase-2 (MMP-2) level and lymph node metastasis in patients with esophagus can-
cer. Methods From March 2011 to September 2014, 83 patients of esophageal cancer treated in our hospital and con-
firmed by postoperative pathological examination were selected as esophageal cancer group, and 21 patients diagnosed
as esophageal cancer preoperatively but confirmed as benign by postoperative pathological examination were enrolled as
the benign group. The positive expression levels of VEGF, CD44v6 and MMP-2 were compared between the two
groups, and the lymph node metastasis in patients with different expression levels was analyzed to explore their correla-
tion. Results The positive expression rate of VEGF, CD44v6 and MMP-2 in esophageal cancer group were 77.11%
(64/83), 73.49% (61/83) and 59.04% (49/83), respectively, which were significantly higher than those in the benign
group of 14.29% (3/21), 23.81% (5/21) and 14.29% (3/21) (P<0.05). The positive expression rate of VEGF, CD44v6 and
MMP-2 in patients with lymph node metastasis were 85.48% (53/62), 82.26% (51/62) and 66.13% (41/62), which were
significantly higher than those in the patients without lymph node metastasis of 52.38% (11/21), 47.62% (10/21) and
38.10% (8/21) (P<0.05). Conclusion The expression levels of VEGF, CD44v6 and MMP-2 in esophageal cancer are
correlated to lymph node or metastasis, which has important significance in the early diagnosis, treatment, and prognosis
assessment of esophageal cancer.

      【Key words】 Lymph node metastasis; Esophageal cancer; Vascular endothelial growth factor (VEGF); CD44
variant 6 (CD44v6); Matrix metalloproteinase-2 (MMP-2)
·论 著·
6350.2016.06.010