标题：小剂量茶碱联合溴化异丙托品治疗COPD急性加重期23例疗效观察

      作者：向明发 1，向旭东 2
    （1.龙山县人民医院，湖南 龙山 416800；
2.中南大学湘雅二医院，湖南 长沙 410011）

      卷次： 2012年23卷19期

      【摘要】 目的 探讨小剂量茶碱与溴化异丙托品联合治疗COPD急性加重期的临床疗效及安全性。方法 将
46例COPD急性加重期患者随机分为观察组和对照组，各23例。观察组给予小剂量茶碱联合溴化异丙托品治疗，
对照组给予溴化异丙托品联合沙丁胺醇治疗，观察两组患者肺功能改善情况及不良反应情况，并进行疗效评定。
结果 两组患者治疗后FEVI、FVC、FEVI百分比及FEVI/FVC水平均较治疗前有明显改善（P<0.05）；观察组治疗
后FEVI、FVC、FEVI百分比及FEVI/FVC水平均明显高于对照组（P<0.05）；观察组治疗总有效率为91.30%，明显
高于对照组的73.91%（P<0.05）；两组不良反应均较轻微，且发生率比较差异无统计学意义(P>0.05)。结论 小剂
量茶碱联合溴化异丙托品治疗COPD急性加重期具有疗效好、见效快、症状缓解明显等优点，且不会增加不良反
应，对改善COPD患者肺功能、提高其生活质量均有积极意义。

      【关键词】 小剂量茶碱；溴化异丙托品；慢性阻塞性肺病；急性加重期

      【中图分类号】 R563 【文献标识码】 A 【文章编号】 1003—6350（2012）19—024—03<

br>Clinical study of low dose theophylline and ipratropium bromide in the treatment of patients with COPD in
acute exacerbation.
XIANG Ming-fa 1, XIANG Xu-dong 2. 1. The People's Hospital of Longshan Country, Longshan
416800, Hunan, CHINA; 2. The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, CHINA

【Abstract】 Objective To investigate the clinical efficacy and safety of low dose theophylline and ipratropi-
um bromide in the treatment of patients with COPD in acute exacerbation. Methods Forty-six patients with COPD
in acute exacerbation were randomly divided into the study group and the control group. The study group was given
low dose theophylline combined with ipratropium bromide, while the control group was given ipratropium bromide
combined with salbutamol, The improvement in lung function and adverse effects in the two groups were observed,
and the efficacy was evaluated. Results After treatment, a significant improvement in the levels of FEV1, FVC,
FEV1% and FEV1/FVC were observed in both groups (P<0.05), The levels of FEV1, FVC, FEV1% and FEV1/FVC
in the study group after the treatment were significantly higher than those of the control group (P<0.05). The total ef-
fective rate of the study group was 91.30%, significantly higher than that in the control group (73.91%), P<0.05. Ad-
verse reactions were mild in both groups, and the incidence of complications showed no statistically significant dif-
ference (P>0.05). Conclusion For treating patients with COPD in acute exacerbation, the combination of low-dose
theophylline and ipratropium bromide is effective and safe and would not increase the adverse reactions, which has a
positive significance on the improvement of pulmonary function and the quality of life for patients with COPD.

      【Key words】 Low dose theophylline; Ipratropium bromide; Chronic obstructive pulmonary disease (COPD);
Acute exacerbation
·临床研究·doi:10.3969/j.issn.1003-6350.2012.19.009