标题：负荷剂量阿托伐他汀对非ST段抬高急性冠状动脉综合征患者PCI围术期的影响

      作者：田 磊
    （西安医学院附属医院心血管内科，陕西 西安 710077）

      卷次： 2012年23卷19期

      【摘要】 目的 探讨负荷剂量阿托伐他汀对非ST段抬高急性冠状动脉综合征(NSTEACS)患者PCI围手术
期的影响。方法 将160例NSTEACS患者随机分为负荷剂量治疗80例为观察组和标准治疗80例为对照组。观察
组PCI术前3~5 d给予负荷剂量阿托伐他汀40 mg/d，对照组PCI术前3~5 d给予常规剂量阿托伐他汀10 mg/d，两组
其余药物治疗均相同，PCI治疗相同。主要检测指标为术前、术后6 h、12 h、24 h肌酸激酶同工酶(CK-MB)、心肌
肌钙蛋白(cTnI)水平变化，随访术后30 d内主要不良心脏事件（MACE）发生率。结果 与PCI术前比较，观察组
术后 8 h、24 h CK-MB、cTnI升高水平均明显低于对照组，两组比较差异具有统计学意义（P<0.05）；观察组术后
30 d内MACE的发生率明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 NSTEACS患者PCI术
前应用负荷剂量阿托伐他汀能减少PCI术对患者造成的心肌损伤，降低PCI术后不良心脏事件的发生率，安全有
效，临床可广泛应用。

      【关键词】 负荷剂量；他汀类；NSTEACS；PCI；介入治疗

      【中图分类号】 R654.2 【文献标识码】 A 【文章编号】 1003—6350（2012）19—022—03<

br>Effect of loading dose of atorvastatin on the PCI perioperative period in patients with non-ST segment
elevation acute coronary syndrome.
TIAN Lei. Department of Cardiology, the Affiliated Hospital of Xi'an Medical
College, Xi'an 710077, Shaanxi, CHINA

【Abstract】 Objective To investigate the loading dose of atorvastatin on the PCI perioperative period in pa-
tients with non-ST segment elevation acute coronary syndrome (NSTEACS). Methods One hundred and sixty pa-
tients with NSTEACS were randomly divided into the observation group and the control group, each with 80 cases.
The observation group was given a loading dose of atorvastatin (40 mg/d) 3~5 days PCI preoperatively, while the con-
trol group was given conventional dose of atorvastatin (10 mg/d) 3~5 days PCI preoperatively. The remaining medica-
tions applied and the PCI treatment performed were the same in the two groups. The levels of creatine kinase isoen-
zyme (CK-MB) and cardiac troponin I (cTnI) were detected before operation, and 8 h, 12 h, 24 h after operation. The
incidence of major adverse cardiac events (MACE) was investigated 30 days after operation. Results The increase in
the levels of CK-MB, cTnI 8 h, 24 h after operation was significantly lower than that in the control group (P<0.05),
compared with the levels before operation. The incidence of MACE of the observation group 30 days after operation
was significantly lower than that of the control group (P<0.05). Conclusion For patients with NSTEACS, the appli-
cation of loading dose of atorvastatin before PCI can lighten the myocardial damage causes by PCI and reduce the inci-
dence of MACE after PCI, which is safe, effective, and worthy to be widely applied in clinic.

      【Key words】 Loading dose; Statins; NSTEACS; PCI; Interventional therapy