标题：海南省2010-2011年手足口病重症病例流行特征比较分析

      作者：曾昭长，金玉明，陈少明，李 臻，黄 芳*
    (海南省疾病预防控制中心，海南 海口 570203)

      卷次： 2012年23卷18期

      【摘要】 目的 了解海南省2010-2011年手足口病重症病例的流行病学特征，掌握疫情变化趋势，为手足口
病重症病例防治工作提供科学依据。方法 采用描述性流行病学方法对手足口病重症病例进行流行病学特征
和病原学检测结果比较分析。结果 海南省 2010年、2011年分别报告重症病例 277例(其中死亡 5例)和 980例
(其中死亡 33例)，重症病例发病率分别为 3.2/10万和 11.30/10万，分别占当年总病例数的 1.10% (277/25 142)和
1.93% (980/50 716)，发病均以 3岁以下儿童为主，男女性别比分别为 2.42:1和 1.95:1，农村地区病例分别占
68.59% (190/277)和 56.73% (556/980)。病原检测阳性率分别为 65.56% (99/151)和 26.06% (184/706)，其中EV71
阳性占总阳性病例的64.6%和80.43%。结论 2011年海南省手足口病疫情强度较2010年明显增强，流行高峰持
续时间和EV71病原构成有较大变化，且西南部地区疫情呈现出快速上升的趋势，加强重点地区和重点人群综合
防控措施仍是防控工作的主要策略。

      【关键词】 手足口病；重症病例；流行特征；调查分析

      【中图分类号】 R18 【文献标识码】 A 【文章编号】 1003—6350（2012）18—125—03<

br>Comparative analysis on the epidemic characteristics of severe HFMD cases in Hainan province from 2010 to
2011.
ZENG Zhao-chang, JIN Yu-ming, CHEN Shao-ming, LI Zhen, HUANG Fang. Hainan Provincial Center for
Disease Control and Prevention, Haikou 570203, Hainan, CHINA

【Abstract】 Objective To analyze the epidemic characteristics of the severe cases of hand foot and mouth dis-
ease (HFMD) in Hainan province from 2010 to 2011, and to provide scientific proof for further prevention of the dis-
ease. Methods The epidemic characteristics and etiology detection results of severe HFMD cases were analyzed
with descriptive epidemiology. Results Two hundred and seventy-seven severe cases of HFMD were reported in
2010, including 5 cases of death, and 980 severe cases of HFMD were reported in 2011, including 33 cases of death.
The incidence of severe HFMD were 3.2/100 000 and 11.30/100 000 in 2010 and 2011, respectively, and the percent-
age of severe cases were 1.10% (277/25 142) and 1.93% (980/50 716), respectively. Most of the cases were below 3
years old, and the gender ratio was 2.42:1 and 1.95:1 in 2010 and 2011, respectively. The percentage of cases from ru-
ral area was 68.59% (190/277) in 2010 and 56.73% (556/980) in 2011. The positive rate of etiology detection was
65.56% (99/151) in 2010 and 26.06% (184/706) in 2011, with the positive percentage of EV71 of 64.6% and 80.43%,
respectively. Conclusion The epidemic intensity of severe HFMD in 2011 is significantly enhanced as compared to
2010. The epidemic peak duration and the constitution of EV71 pathogen changes significantly. The epidemic situa-
tion in the southwest area exhibits a rapid upward trend. Strengthening control in the key areas and focusing on the
main groups are the main strategy for the management of the disease.

      【Key words】 Hand foot and mouth disease; Severe cases; Epidemic characteristics; Analysis
·疾病监控·