标题：42例EDTA依赖性血小板减少症患者的检测分析

      作者：龙 聪，郭 辉，杨章元
    （荆州市长江大学附属第一医院检验科，湖北 荆州 434000）

      卷次： 2012年23卷15期

      【摘要】 目的 初步分析EDTA依赖性血小板减少的现象及原因。方法 对 42例EDTA依赖性血小板减
少患者重新抽血，检测不同时间段血小板和白细胞的变化并与手工计数相比较，同时检测其血沉和免疫球蛋
白。结果 EDTA-K2抗凝血血小板和白细胞在 10 min内上机检测，其结果与手工法差异无统计学意义(P＞
0.05)，但在30 min以后与手工法差异有统计学意义(P＜0.05)；比较EDTA依赖性血小板减少症患者和健康对照
者的血沉、IgG及 IgM，差异有统计学意义(P＜0.05)，而 IgA差异不明显。结论 EDTA依赖性血小板减少症可能
与血小板本身、自身抗体及其他疾病因素有关，应引起临床重视。

      【关键词】 EDTA依赖性血小板减少；血沉；免疫球蛋白

      【中图分类号】 R446.11 【文献标识码】 B 【文章编号】 1003—6350（2012）15—100—02<

br>Clinical analysis of 42 cases of EDTA-dependent thrombocytopenia.
LONG Cong, GUO Hui, YANG Zhang-yuan.
The Department of Clinical Laboratory, the First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei, CHINA

【Abstract】 Objective To investigate the phenomenon and causes of EDTA-dependent thrombocytopenia.
Methods The blood of 42 patients with EDTA-dependent thrombocytopenia were collected. The changes in platelet
and leukocyte counts in different time periods were detected by machine and compared to that by manual count. The
erythrocyte sedimentation rate and immunoglobulin were also tested. Results Detected within 10 min on the ma-
chine, the results of EDTA-K2 anti-clotting platelets and white blood cells showed no statistically significant differ-
ence from the results obtained by manual methods (P>0.05), but the difference was statistically significant after 30
min (P<0.05). The erythrocyte sedimentation rate, IgM and IgG was statistically significant different in EDTA-depen-
dent thrombocytopenia patients and healthy controls (P<0.05), while IgA was not. Conclusion EDTA-dependent
thrombocytopenia might be correlated to its own platelet, antibodies and disease, which should be paid more attention
to in clinical practice.

      【Key words】 EDTA-dependent thrombocytopenia; ESR; Immunoglobulin