标题:妈富隆联合二甲双胍治疗肥胖型青春期多囊卵巢综合征30例疗效观察
作者:李雅琪,马 燕,宋致蓉,彭 俊,廖国芳,张 瑜
(凉山州第一人民医院妇产科,四川 西昌 615000)
卷次:
2012年23卷15期
【摘要】 目的 观察妈富隆联合二甲双胍治疗肥胖型青春期多囊卵巢综合征患者内分泌代谢紊乱的疗
效。方法 对30例肥胖型青春期多囊卵巢综合征患者给予妈富隆联合二甲双胍治疗3个月,观察治疗前后性激
素指标、糖代谢指标、体重指数、面部痤疮评分等变化情况。结果 患者LH、T及LH/FSH比值均较治疗前下降
(P<0.05),FSH、E2、PRL、P及空腹血糖则无明显变化(P>0.05),空腹胰岛素、葡萄糖曲线下面积下降(P<0.05),胰
岛素曲线下面积、HOMA-IR明显下降(P<0.01);体重指数及腰臀比下降。结论 妈富隆联合二甲双胍对降低肥
胖型青春期多囊卵巢综合征雄激素水平,改善胰岛素抵抗,恢复正常月经周期有明显效果。
【关键词】 青春期;多囊卵巢综合征;肥胖型;二甲双胍;妈富隆
【中图分类号】 R473.6 【文献标识码】 A 【文章编号】 1003—6350(2012)15—076—03<
br>Clinical observation of marvelon combined with metformin in the treatment of 30 cases of pubertal polycystic
ovary syndrome.
LI Ya-qi, MA Yan, SONG Zhi-rong, PEN Jun, LIAO Guo-fang, ZHANG Yu. The First People's
Hospital of Liangshan Prefecture, Xichang 615000, Sichuan, CHINA
【Abstract】 Objective To study the clinical efficacy of marvelon combined with metformin in the treatment
of pubertal polycystic ovarian syndrome: effect of endocrine and metabolic disorders. Methods Thirty obese adoles-
cent girls with polycystic ovarian syndrome were given marvelon combined with metformin for 3 months. The sex hor-
mone indexes, indices of glucose metabolism, body mass index, facial acne score changes were observed before and
after treatment. Results After treatment, LH, T and LH / FSH ratio decreased than that before treatment (P<0.05),
while FSH, E2, PRL, P and fasting glucose showed no significant change (P>0.05). The area under fasting insulin
curve and glucose curve decreased significantly (P<0.05), and the area under the insulin curve was marked significant-
ly decreased (P<0.01). The insulin resistance index of HOMA-IR decreased significantly (P<0.01), and the body mass
index and waist-hip ratio also declined. Conclusion Marvelon combined with metformin is quite effective in reduc-
ing obesity of pubertal polycystic ovary syndrome and androgen levels, improving insulin resistance and recovering
normal menstrual cycles.
【Key words】 Puberty; Polycystic ovarian syndrome; Obesity; Metformin; Marvelon
·临床经验·
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