标题：抑郁症与躁狂症患者心肌酶谱比较分析

      作者：占达飞，姚乾坤，陈 雄，黄 胜，杨庆雄，谢 曼，刘向来
    （海南省安宁医院，海南 海口 571100）

      卷次： 2012年23卷15期

      【摘要】 目的 探讨抑郁症患者与躁狂症患者的心肌酶谱差异特征，分析其相关的影响因素。方法 筛选
40例汉族抑郁症患者和38例躁狂症患者纳入研究对象，采用汉密尔顿抑郁量表(HAMD)、焦虑量表（HAMA）、躁
狂评定量表（BRMS）评定临床症状严重程度，检测心肌酶五项。采用SPSS13.0软件统计分析。结果 入院时抑
郁症患者组与躁狂症患者组心肌酶五项中磷酸肌酸激酶（CK）（χ 2=4.863，P＜0.01）、磷酸肌酸激酶同工酶
（CK-MB）（χ2=8.642，P＜0.01）、乳酸脱氢酶（LDH）（χ2=3.297，P＜0.05）比较差异有统计学意义，羟丁酸脱氢酶
（α-HBDH）以及同型半胱氨酸（HCY）在两组间没有阳性发现。躁狂症患者BRMS评定临床症状严重程度与心肌
酶五项中CK（r=0.429，P＜0.01）、CK-MB（r=0.283，P＜0.05）、LDH（r=0.214，P＜0.05）呈正相关性。结论 躁狂症
患者心肌酶三项指标明显高于抑郁症患者，且躁狂症患者临床严重程度与心肌酶五项呈正相关。

      【关键词】 抑郁症；躁狂症；心肌酶谱

      【中图分类号】 R749.4 【文献标识码】 A 【文章编号】 1003—6350（2012）15—033—02<

br>Comparative analysis on myocardium enzymes spectrum in 40 patients with mania and 38 patients with
depression.
ZHAN Da-fei, YAO Qian-kun, CHEN Xiong, HUANG Sheng, YANG Qing-xiong, XIE Man, LIU Xiang-lai.
Anning Hospital of Hainan province, Haikou 571100, Hainan, CHINA

【Abstract】 Objective To analyze the myocardium enzymes spectrum in 40 manic patients (group A) and 38 de-
pressive patients (group B), and analyze the influence factors. Methods Thirty eight manic patients and 40 depressive
patients were enrolled in this study. The clinical symptoms of the patients were assessed by HAMD, HAMA, BRMS.
Meanwhile, the venous blood samples were collected for assay of myocardium enzymes spectrum. Results The two
groups showed statistically significant difference in creative kinase (CK, χ 2=4.863,P<0.01), creatine kinase Isoen-
zyme-MB (CK-MB, χ2=8.642, P<0.01), and lactate dehydrogenase (LDH, χ2=3.297, P<0.05), with no statistically significant
difference inα-Hydroxybutyrate dehydrogenase (α-HBDH) and homocysteine (HCY). BRMS scores in the manic patients
were highly correlated with CK (r=0.429, P<0.01), CK-MB (r=0.283, P<0.01), LDH (r=0.214, P<0.05). Conclusion The
manic patients had higher levels than depressive patients in the myocardium enzymes spectrum.

      【Key words】 Depression; Mania; Myocardium enzymes spectrum
基金项目：海南省卫生厅课题（编号：琼卫2011-103号）