标题：手术切除 IIIA期-N2非小细胞肺癌预后影响因素分析

      作者：罗 强，蓝碧洋*，钟醒能，黄绍华，张晓安，黄斯阳
    (广西壮族自治区民族医院外二科，广西 南宁 530001)

      卷次： 2012年23卷12期

      【摘要】 目的 分析手术切除 IIIA期-N2非小细胞肺癌患者预后的影响因素。方法 回顾性分析1996年3
月至2007年1月在我院行手术治疗的124例 IIIA期-N2非小细胞肺癌患者的临床资料，分析各种可能影响其生
存率的因素，使用Kaplan-Meier方法分析生存率，应用Log-rank方法对各单因素与预后的关系进行检验，使用
Cox模型对多因素进行分析。结果 患者在术后的1年、3年、5年的生存率分别是65.7%、48.2%、17.3%，单因素分
析中，肿瘤的切除情况、N2淋巴结发生转移的个数、淋巴结发生转移的组数、术后的化疗情况都对生存率有影响。
多因素分析显示，N2淋巴结发生转移的个数、术后的化疗情况是预后的主要影响因素。结论 ⅢA期-N2非小细
胞肺癌的患者术后生存率比较低，对预后生存率影响最大的是N2淋巴结发生转移的个数以及化疗情况。

      【关键词】 非小细胞肺癌；手术切除；预后；影响因素

      【中图分类号】 R734.2 【文献标识码】 A 【文章编号】 1003—6350(2012)12—009—03<

br>Influencing factors on the prognosis of the surgical resection of stage ⅢA-N2 non-small cell lung cancer.
LUO
Qiang, LAN Bi-yang, ZHONG Xing-neng, HUANG Shao-hua, ZHANG Xiao-an, HUANG Si-yang. The Second
Department of Surgery, Minzhu Hospital of Guangxi Zhuang Autonomous Region, Nanning 530001, Guangxi, CHINA

【Abstract】 Objective To analyze the influencing factors on the prognosis of the surgical resection of stage
Ⅲ A-N2 non-small cell lung cancer (NSCLC). Methods The clinical data of 142 patients of Ⅲ A-N2 NSCLC re-
ceived surgical resection from March 1996 to January 2007 in our hospital were retrospectively analyzed. The factors
that might affect the survival rate was analyzed using the Kaplan-Meier method. The relationship between each single
factor and the prognosis was tested with Log-rank, using the Cox model analysis multivariate. Results The 1-year,
3-year, 5-year survival rates were 65.7%, 48.2%, 17.3%, respectively. According to univariate analysis, tumor resec-
tion, the transferred number of N2 lymph node, the transferred number of lymph node group, postoperative chemother-
apy were found to exert an impact on the survival rate. Conclusion The survival rate of patients withⅢ A stage-N2
NSCLC was low. The factors influencing the prognosis mostly were the transferred number of N2 lymph node, and
the cycles of chemotherapy.

      【Key words】 Non-small cell lung cancer; Surgery; Prognosis; Influencing factor
doi:10.3969/j.issn.1003-6350.2012.12.004