标题：海南黎族哮喘ORMDL3基因多态性研究

      作者：丁毅鹏 1，何海武 2，石慧芳 2，林 莉 2，陈 山 2，姚红霞 1
    （1.海南省人民医院急救中心，海南 海口 570311；
2.海南省农垦总医院，海南 海口 570311）

      卷次： 2012年23卷11期

      【摘要】 目的 探讨海南黎族哮喘与ORMDL3基因多态性的关系。方法 采用聚合酶链反应-限制性片
段长度多态性(PCR-RFLP）等方法对 120例黎族哮喘患者ORMDL3基因多态性进行观察，并与 150例正常对照
组进行对比。结果 哮喘组 rs7216389位点 TT型基因与对照组比较差异有统计学意义（P<0.05）；哮喘组
rs11650680位点TT型和CC型与对照组比较差异有统计学意义（P<0.05）。结论 ORMDL3基因多态性变化可
能与黎族哮喘患者发病有一定的相关性。

      【关键词】 ORMDL3；哮喘；黎族；基因多态性

      【中图分类号】 R562.+5 【文献标识码】 A 【文章编号】 1003—6350（2012）11—001—02<

br>Genetic polymorphism of ORMDL3 gene in patients with asthma in Li nationality of Hainan province.
DING
Yi-peng 1, HE Hai-wu 2, SHI Hui-fang 2, LIN Li 2, CHEN Shan 2, YAO Hong-xia 1. 1. Department of Emergency, People's
Hospital of Hainan Province, Haikou 570102, Hainan, CHINA; 2. Hainan Provincial Hospital of General Bureau of
Agriculture, Haikou 570311, Hainan, CHINA

【Abstract】 Objective To explore the relationship between the genetic polymorphism of ORMDL3 gene and
asthma in Li Nationality of Hainan province. Methods Polymerase chain reaction-restriction fragment length poly-
morphism (PCR-RLFP) was used to detect the genetic polymorphism of ORMDL3 gene in 120 patients with asthma
in Li Nationality (the asthma group) and in 150 normal individuals (the control group). Results There was statistical-
ly significant difference in TT gene of rs7216389, TT and CC gene of rs11650608 between the asthma group and the
control group. Conclusion The genetic polymorphism of ORDL3 gene showed a certain correlation with the asthma
of Li nationality.

      【Key words】 ORMDL3; Asthma; Li nationality; Genetic polymorphism
基金项目：海南省自然科学基金资助项目（编号：30222）