标题：老年高血压患者血清尿酸水平与颈动脉粥样硬化的相关性

      作者：蓝活，梁立燕，汪涛
    (深圳市龙岗区第七人民医院急诊内科，广东 深圳 518114)

      卷次： 2016年27卷5期

      【摘要】 目的 探讨老年高血压患者血清尿酸水平与颈动脉粥样硬化的关系。方法 选取2014年1月至2015
年5月我院心内科诊治的109例老年高血压患者，根据患者的血尿酸及颈动脉内膜中层厚度(IMT)水平将其分别分
为高尿酸组(n=42)与正常尿酸组(n=67)、IMT正常组(n=45)与 IMT增厚组(n=64)，比较各组患者的血脂、尿酸、颈动
脉 IMT等指标，其中血脂、尿酸采用全自动生化分析仪检测，颈动脉 IMT采用彩色多普勒超声检查测量。结果 本
组109例患者中高尿酸血症发生率为 38.53% (42例)；高尿酸组患者血甘油三酯(TG) [(2.83±1.24) mmol/L]、总胆
固醇(TC) [(5.80±1.31) mmol/L]、低密度脂蛋白(LDL) [(3.97±0.98) mmol/L]及颈动脉 IMT水平 [(1.08±0.19) mm]均
明显高于正常尿酸组 [(2.28±1.12) mmol/L、(5.32±1.13) mmol/L、(3.61±0.82) mmol/L、(0.98±0.12) mm]，差异均有统
计学意义(P<0.05)；IMT增厚组患者血尿酸水平为(419.28±60.17) ?mol/L，高尿酸血症发生率为 51.11% (23/45)，
分别高于 IMT正常组的(345.92±52.09) ?mol/L及 29.69% (19/64)，差异均有统计学意义(P<0.05)；相关性分析显
示，老年高血压患者血尿酸水平与颈动脉 IMT呈正相关(r=0.732，P<0.05)。结论 老年高血压患者血尿酸水平
与颈动脉 IMT呈正相关，可作为反映颈动脉粥样硬化的可靠指标。

      【关键词】 老年；高血压；尿酸；颈动脉粥样硬化；相关性

      【中图分类号】 R544.1 【文献标识码】 A 【文章编号】 1003—6350（2016）05—0720—03


Correlation of serum uric acid with carotid atherosclerosis in elderly patients with hypertension.
LAN Huo, LIANG
Li-yan, WANG Tao. Department of Emergency Internal Medicine, the Seventh People's Hospital of Longgang District of
Shenzhen, Shenzhen 518114, Guangdong, CHINA

【Abstract】 Objective To investigate the relationship between serum uric acid (UA) and carotid atherosclerosis
in elderly patients with hypertension. Methods A total of 109 elderly patients with hypertension in our hospital from
Jan. 2014 to May 2015 were divided into high UA group (n=42) and normal UA group (n=67) according to the level of
UA, as well as normal carotid artery intima-media thickness (IMT) group (n=45) and IMT thickening group (n=64) ac-
cording IMT. The lipid, uric acid, carotid IMT were compared, the blood lipids and uric acid were detected by automatic
biochemistry analyzer, and carotid artery IMT were measured by color Doppler ultrasound. Results The incidence of hy-
peruricemia in the 109 patients was 38.53% (42 patients). The levels of serum triglyceride (TG), total cholesterol (TC), low
density lipoprotein (LDL) and carotid artery IMT in the high UA group were significantly higher than those in the normal
UA group [(2.83±1.24) mmol/L vs (2.28±1.12) mmol/L, (5.80±1.31) mmol/L vs (5.32±1.13) mmol/L, (3.97±0.98) mmol/L
vs (3.61±0.82) mmol/L, (1.08±0.19) mm vs (0.98±0.12) mm, P<0.05]. The serum UA level and incidence of hyperurice-
mia in IMT thickening group were (419.28±60.17) μmol/L and 51.11% (23/45) respectively, which were significantly
higher than those in the normal IMT group of (345.92±52.09) μmol/L and 29.69% (19/64), P<0.05. Correlation analysis
showed that uric acid was positively correlated with carotid IMT in elderly patients with hypertension (r=0.732, P<0.05).
Conclusion Uric acid is positively correlated with carotid IMT in elderly patients with hypertension, and it can serve
as a reliable indicator for carotid atherosclerosis.

      【Key words】 Elderly; Hypertension; Uric acid; Carotid atherosclerosis; Correlation
·论 著·
6350.2016.05.010