标题：血小板参数测定在血小板减少症中的临床应用价值

      作者：田一娟 1，吴起武 2，严达尊 1，曹洪铭 3
    (陈星海医院检验科 1、儿科 2、理疗科 3，广东 中山 528415)

      卷次： 2012年23卷9期

      【摘要】 目的 探讨骨髓性与非骨髓性血小板减少症患者血小板参数变化及其临床意义。方法 将血小板
减少症患者分为骨髓性血小板减少症组(53例)和非骨髓性血小板减少症组(25例)，选择100例健康人作为对照
组。用KX-21型血细胞分析仪测定各组静脉血的血小板总数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)
及血小板分布宽度(PDW)，分析各组间 PLT、MPV、PCT、PDW的变化。结果 骨髓性血小板减少症患者 PLT、
PCT均低于对照组，t值分别为32.787、35.858，P值均为0.000，MPV和PDW则差异无统计学意义，t值(P值)分别
为 1.080(0.282)、0.664(0.508)；非骨髓性血小板减少症患者PLT、PCT均低于对照组，t值分别为24.296、5.820，P值
均为0.000，而MPV和PDW高于对照组，t值分别为9.842、22.666，P值均为0.000；骨髓性血小板减少症患者MPV
和PCT低于非骨髓性血小板减少患者，t值分别为6.297、2.217，P值分别为0.000、0.030。结论 血小板减少症患
者MPV正常时提示可能为骨髓性疾病引起，MPV增大提示可能为非骨髓性疾病引起。

      【关键词】 血小板减少症；血小板参数；骨髓性；非骨髓性

      【中图分类号】 R446.11 【文献标识码】 A 【文章编号】 1003—6350(2012)09—097—02<

br>Clinical application of platelet parameters in Thrombocytopenia.
TIAN Yi-juan 1, WU Qi-wu 2, YAN Da-zun 1,CAO
Hong-ming 3. Department of Clinical Laboratory 1, Department of Pediatrics 2, Department of Physiotherapy 3, Chenxing-
hai Hospital, Zhongshan 528415 Guangdong, CHINA

【Abstract】 Objective To investigate the change of platelet parameters and its clinical significance in mar-
row and non-marrow thrombocytopenia (TP) patients. Methods Platelet count (PLT), mean platelet volume (MPV),
plateletcrit (PCT) and platelet distribution width (PDW) of 53 marrow TP patients (group A), 25 non-marrow TP pa-
tients (group B) and 100 healthy individuals (the control group) were respectively determined by KX-21 blood cell an-
alyzer, and then the changes of PLT, MPV, PCT and PDW were analyzed in the three groups. Results Compared
with the control group, PLT and PCT of group A are lower (t values were 32.787 and 35.858, respectively and the P
values were both 0.000). MPV and PDW showed no statistically significant difference between the control group and
group A, with t values (P values)=1.080 (0.282) and 0.664 (0.508), respectively. Compared with the control group,
PLT and PCT of group B are lower (t values were 24.296 and 5.820, respectively, and P values were both 0.000).
MPV and PDW of group B were higher than that of the control group, with t values of 9.842 and 22.666, respectively
and P values both of 0.000. MPV and PCT of the group A were lower than that of group B, with t values of 6.297 and
2.217, respectively and P values of 0.000 and 0.030, respectively. Conclusion For thrombocytopenia patients, if the
MPV is normal, thrombocytopenia might be caused by bone marrow diseases; if MPV is higher than the normal value,
thrombocytopenia might be caused by non-marrow diseases.

      【Key words】 Thrombocytopenia; Platelet parameters;Marrow; Non-marrow