标题：女性痛风的临床特点及危险因素分析

      作者：程秀峰，祝 英，张 彦，陆 璧，董 晶
    (张家港澳洋医院风湿内分泌科，江苏 张家港 215600)

      卷次： 2012年23卷8期

      【摘要】 目的 了解女性痛风的临床特点及相关危险因素。方法 回顾性分析本院23例女性痛风患者的
临床资料，并与149例男性痛风患者资料相比较。结果 23例女性痛风平均发病年龄(58.7±17.4)岁，149例男性
痛风平均发病年龄(46.2±16.7)岁(P<0.01)。女性痛风BMI (22.4±3.2)，男性为(26.8±4.6)，P<0.05。女性痛风患者
首发关节炎 65.2%为下肢踝/膝关节，73.8%男性患者为足第一跖趾关节；病程中 65.2%女性患者上肢关节受累，
77.9%男性患者足第一跖趾关节受累。52.2%女性痛风患者伴发冠心病，而男性组仅为21.5% (P<0.05)。56.5%女
性患者服用利尿剂、阿斯匹林或化疗药物。痛风结晶、尿酸性肾病、高脂血症、高血压病及糖尿病两组间差异无
统计学意义。结论 女性痛风患者发病年龄较大，体型偏瘦，多服用利尿剂等药物；以下肢踝及膝关节首发多
见，多累及上肢关节；易伴发冠心病，应引起临床重视。

      【关键词】 痛风；女性；临床特点；危险因素

      【中图分类号】 R589.7 【文献标识码】 A 【文章编号】 1003—6350(2012)08—023—02<

br>Clinical features and risk factors of woman with gout.
CHENG Xiu-feng, ZHU Ying, ZHANG Yan, LU Bi, DONG
Jing. Department of Rheumatology, Aoyoung Hospital of Zhangjiagang City, Zhangjiagang 215600, Jiangsu, CHINA

【Abstract】 Objective To evaluate the clinical features and risk factors of woman with gout. Methods The
clinical data of twenty-three women with gout were analyzed and compared with that of 149 males with gout.
Results The mean age at onset of gout was (58.7±17.4) years in woman. Body mass index (BMI) was (22.4±3.2). Al-
though the initial manifestation of the disease was acute monoarticular arthritis, with involvement of the ankle or knee
joint being more commonly observed in female patients (65.2%) than the male patients, and by contrast, with involve-
ment of podagra being more frequently noted in the males (73.8%) than in the females (26.1%). The females showed a
higher frequency of upper limb joint involvement (65.2% ), and podagra was less frequently evident in the females
(30.4%). Coronary artery disease was more existed in the females (52.2%). The females (56.5%) received more diuret-
ics, aspirin or chemotherapeutics before gout onset. Conclusion The females showed less BMI, and seems to be
more involved in the upper limb and more likely to have coronary artery disease.