标题：GnRH受体在人类子宫内膜的表达及意义

      作者：谢凤云 1，谢梅青 2
    (1.珠海市妇幼保健院妇科，广东 珠海 519000；
2.广州市中山大学附属第二医院妇科，广东 广州 510120)

      卷次： 2012年23卷7期

      【摘要】 促性腺激素释放激素(GnRH)在体内的生理调节功能是由促性腺激素释放激素受体(GnRH-R)介导
的，GnRH与受体的结合具有高度特异性。研究发现，GnRH和GnRH-R除位于下丘脑垂体系统外，在机体的其他
组织，尤其是生殖器官也有分布。近年来有许多对人类不同类型子宫内膜表达GnRH-R的研究报道，推测子宫内
膜GnRH和GnRH-R系统在调节子宫内膜的自分泌或旁分泌中起重要作用，并参与子宫内膜的增殖调节。

      【关键词】 促性腺激素释放激素受体；促性腺激素释放激素；子宫内膜

      【中图分类号】 R33 【文献标识码】 A 【文章编号】 1003—6350（2012）07—114—03<

br>Expression of GnRH receptor in human endometrium and its significance.
XIE Feng-yun, XIE Mei-qing. 1. De-
partment of Gynecology, Maternal and Child Health Hospital of Zhuhai City, Zhuhai 519000, Guangdong, CHINA；2.
Department of Gynecology，the Second Affliated Hospital of Sun Yat-sen University, Guangzhou 510120, Guangdong, CHINA
【Abstract】 Gonadotrophin-releasing hormone (GnRH), mediated by its specific GnRH receptor (GnRHR),
plays an important role in the control of mammalian reproduction and stimulates the synthesis and release of luteiniz-
ing hormone and follicle-stimulating hormone. Increasing evidence indicates that GnRH and GnRHR also express in
peripheral tissues except the hypothalamic-pituitary system, especially in reproductive system. To date, plenty of re-
search about the GnRH-R in human endometrium presumes that GnRH-GnRHR system may contribute to the control
of auto-or paracrine of endometrium.

      【Key words】 Gonadotropin-releasing hormone receptor (GnRH-R); Gonadotropin-releasing hormone (GnRH);
Endometrium