标题：miR-137基因rs1625579多态性与精神分裂症发病风险的Meta分析

      作者：罗旭东，林举达，邹晓波，殷静雯
    (广东医学院附属医院精神心理科，广东 湛江 524001)

      卷次： 2016年27卷4期

      【摘要】 目的 系统评价miR-137 rs1625579位点基因多态性与精神分裂症发病风险的关系。方法 计算机
检索 PubMed、Embase、Springer Link、Wiley Online Library、HighWire Press、Google Scholar和CNKI数据库以获取
2015年8月之前发表的关于miR-137单核苷酸多态位点 rs1625579基因多态性与精神分裂症发病的病例对照研究
文献，采用Review Manager5.0和Stata12.0统计软件进行统计分析。结果 最终纳入8篇，miR-137基因 rs1625579
位点多态性与精神分裂症在显性模型(TT+GT vs GG)、隐性模型(TT vs GT+GG)、加性模型(TT vs GG)和等位基因模
型(T vs G)分析中差异有统计学意义(P<0.05)。合并OR值分别为 1.47、1.21、1.53、1.17；P值分别为 0.03、0.001、
0.02、0.003。结论 miR-137单核苷酸多态性位点 rs1625579与精神分裂症的易感性均具显著相关，为miR-137多
态性与精神分裂症关联性的研究提供了理论参考。

      【关键词】 精神分裂症；miR-137；rs1625579；多态性；Meta分析

      【中图分类号】 R749.3 【文献标识码】 A 【文章编号】 1003—6350（2016）04—0656—04


Correlation between single nucleotide polymorphism rs1625579 in miR-137 gene and schizophrenia: a
meta-analysis.
LUO Xu-dong, LIN Ju-da, ZOU Xiao-bo, YIN Jing-wen. Department of Psychiatry, the Affiliated Hospital
of Guangdong Medical College, Zhanjiang 524001, Guangdong, CHINA

【Abstract】 Objective To assay the association between the single nucleotide polymorphism (rs1625579) in
miR-137 gene and schizophrenia. Methods Studies about the effects of rs1625579 in miR-137 gene on the sensitivity
in patients with schizophrenia until Aug. 2015 were searched from PubMed, Embase, Springer Link, Wiley Online Li-
brary, HighWire Press, Google Scholar, and China National Knowledge Infrastructure (CNKI). Meta-analysis was per-
formed by using Review Manager5.0 and Stata12.0. Results A total of 8 studies were included. A significant associa-
tion between rs1625579 and schizophrenia was found using dominant [TT+GT vs GG, P=0.03, odds ratio (OR)=1.47], re-
cessive (TT vs GT+GG, P=0.001, OR=1.21), additive (TT vs GG, P=0.02, OR=1.53), and allele (T vs G, P=0.003, OR=
1.17) models. Conclusion The results of our study provide convincing evidence that rs1625579 is significantly associ-
ated with schizophrenia.

      【Key words】 Schizophrenia; miR-137; rs1625579; Polymorphism; Meta-analysis
·荟萃分析·
6350.2016.04.050