标题：老年患者上消化道出血与服用小剂量阿司匹林的关系探讨

      作者：祝玲，王健儿
    （广东省人民医院广东省医学科学院，广东广州510080）

      卷次： 2012年23卷6期

      【摘要】目的探讨长期服用小剂量阿司匹林的老年患者上消化道出血的发生情况。方法收集281 例长
期服用小剂量阿司匹林的老年患者，74 例在服药过程中发生上消化道出血者为出血组，其余无出血的207 例为
非出血组，行胃镜检查了解胃、十二指肠损伤情况并进行幽门螺杆菌(Hp)的检测，分析其上消化道出血的影响因
素。结果上消化道出血的发生率为26%（74/281），出血组在年龄＞65 岁、既往出血病史、Hp感染中的比率显著
高于非出血组（P＜0.01）。结论长期小剂量服用阿司匹林可增加老年患者上消化道出血的危险性，Hp感染、过
去出血史、年龄是主要的影响因素。

      【关键词】老年患者；上消化道出血；小剂量；阿司匹林

      【中图分类号】573.2 【文献标识码】A 【文章编号】1003—6350（2012）06—046—02
r>Relationship between upper digestive tract bleeding in elderly patients and long term administration of low-dose
aspirin.
ZHU Ling, WANG Jian-er. People's Hospital of Guangdong Province, Guangzhou 510080, Guangdong, CHINA
【Abstract】Objective To investigate the relationship between the upper digestive tract bleeding in elderly patients
and long term administration of low-dose aspirin. Methods The clinical data of 281 elderly patients who administrated
with low-dose aspirin for a long time were collected, including 74 patients with digestive tract bleeding (the bleeding
group) and 207 patients without digestive tract bleeding (the non-bleeding group). Endoscopic examination were performed
to identify the mucosal injuries and Helicobacter pylori infection were tested. Results The incidence of upper digestive
tract bleeding was 26% (74/281). In the bleeding group, patients were more likely to be older than 65 years
old, had a bleeding history and with Helicobacter pylori infection (P<0.01). Conclusion Long term use of low-dose
aspirin in elderly patients increase the danger to develop upper digestive tract bleeding, and age older than 65 years
old, a bleeding history and Helicobacter pylori infection are predominant risk factors.
【Key words】Elderly patients; Upper gastrointesting bleeding; Smalldose; Aspirin