标题：深圳地区396 例非糖尿病高血压患者糖化血红蛋白水平调查

      作者：陈卫东，张毅，晏耀明，肖琴，周薇
    （北京大学深圳医院检验科，广东深圳518036）

      卷次： 2012年23卷5期

      【摘要】目的调查分析深圳地区非糖尿病高血压住院患者糖化血红蛋白水平，为其合理治疗提供参考信
息。方法检测396 例非糖尿病高血压及合并心功能不全住院患者的空腹血糖（FPG）、空腹胰岛素（Fins）和糖
化血红蛋白（HbAlc）。调查对象分为三组：Ⅰ组（单纯原发性高血压）、Ⅱ组（原发性高血压心功能I~Ⅱ级）和Ⅲ组
（原发性高血压心功能Ⅱ级以上）。结果调查对象FPG、Fins 和HbAlc 平均水平分别为（5.93±2.37)mmol/L、
(8.01±4.50) μU/ml 和(6.75±1.44)%。组间FPG 平均水平差异无统计学意义(P>0.05)。Ⅱ组和Ⅲ组患者的Fins 和
HbAIc平均水平高于Ⅰ组，差异有统计学意义(P<0.05)。结论深圳地区原发性高血压患者中，近1/3 患者存在
不同程度糖化血红蛋白水平升高，HbAlc是引起心功能不全的危险因素之一。

      【关键词】原发性高血压；空腹血糖；糖化血红蛋白

      【中图分类号】R544.1 【文献标识码】A 【文章编号】1003—6350（2012）05—082—02
r>Investigation on the levels of HbAlc in 396 non-diabetic patients with essential hypertension.
CHEN Wei-dong,
ZHANG Yi, YAN Yao-ming, XIAO Qin, ZHOU Wei. Department of Laboratory, Peking University Shenzhen Hospital,
Shenzhen 518036, Guangdong, CHINA
【Abstract】Objective To investigate the levels of HbAlc in non-diabetic patients with essential hypertension
in Shenzhen City, and provide references for the reasonable treatment of the patients with essential hypertension.
Methods Fasting plasma glucose (FPG), fasting insulin (Fins) and HbAlc were detected in 396 non-diabetic patients
with essential hypertension without other diseases. The levels of HbAlc were compared in patients with essential hypertension
alone (group Ⅰ), patients with essential hypertension and cardiac function grade Ⅰ~Ⅱ (group Ⅱ), as well
as patients with hypertensive heart function grade Ⅲ (group Ⅲ). Results The average levels of FPG, FINS and
HbAlc were in the three groups (5.93±2.37) mmol/L, (8.01±4.50) μU/ml and (6.75±1.44)%, respectively. FPG showed
no statistically significant difference among the three groups (P>0.05). The average levels of Fins and HbAlc in group
Ⅱ and group Ⅲ were significantly higher than those in group Ⅰ (P<0.05). Conclusion Nearly one third of the
non-diabetic patients with essential hypertension living in Shenzhen City have elevated HbAlc level in varying degrees,
and the elevated HbAlc level is one of the risk factors which associated with cardiac insufficiency.
【Key words】Essential hypertension; Fasting plasma glucose; Glycosylated hemoglobin