标题：妊娠合并特发性血小板减少性紫癜36 例临床分析

      作者：李秀彦，茹美艳
    （海南省人民医院产科，海南海口570311）

      卷次： 2012年23卷5期

      【摘要】目的探讨妊娠合并特发性血小板减少性紫癜（ITP）母婴结局。方法回顾性分析2002 年1 月至
2009 年12 月间妊娠合并ITP 患者临床资料，参照第二届全国血液病学术会议制定的ITP 诊断标准，按治疗时血
小板计数情况分组，血小板计数（50~100）×109/L 为Ⅰ组共14 例，血小板计数＜50×109/L 为Ⅱ组共22 例。记录Ⅱ
组ITP 患者给予糖皮质激素(泼尼松)，丙种球蛋白及(或) 血小板悬液治疗后的临床效果及其母儿的围产结局。
结果两组患者治疗前凝血功能、临床表现比较差异有统计学意义，经治疗后产后出血、新生儿ITP、颅内出血比
较差异无统计学意义。仅分娩方式比较差异有统计学意义（Ⅱ组患者剖宫产率较高）。结论妊娠合并ITP 对母
儿均有潜在的危险，加强围产期管理，根据轻重程度积极治疗可改善妊娠结局。

      【关键词】妊娠并发症；血小板减少；围产期学

      【中图分类号】R714.25 【文献标识码】A 【文章编号】1003—6350（2012）05—065—02
r>Clinical analysis on 36 pregnancy women with idiopathic thrombocytopenic purpura.
LI Xiu-yan, RU Mei-yan.
Department of Obsetrics, People's Hospital of Hainan Province, Haikou 570311, Hainan, CHINA
【Abstract】Objective To investigate the outcome of pregnancy women with idiopathic thrombocytopenic
purpura (ITP) and their infants. Methods The clinical data of 36 pregnancy women with ITP in People’s Hospital
of Hainan Province from Jan. 2002 to Dec. 2009 were analyzed. The patients were divided into two groups according
blood platelets count (BPC), GroupⅠ[BPC (50~100)×109/L, n=14], and Group Ⅱ [BPC<50×109/L, n=22]. The outcome
of mothers and infants as well as the therapeutic efficacy in Group Ⅱ after treated by glucocorticoids, gamma
globulin and transfusion of platelets were recorded. Results The patients’blood clotting function and clinical situation
before operation showed statistically significant difference between the two groups, but postpartum hemorrhage,
neonatus's ITP and intracranial hemorrhage had no statistically significant difference after treatment. The rate of cesarean
delivery in group Ⅱ were significantly higher than that in group Ⅰ. Conclusion Pregnancy combined with ITP
exerts risks for both mother and infants. The outcome of pregnancy could be improved by intensive management and
active treatment.
【Key words】Pregnancy complications; Thrombocytopenia; Perinatology