标题：雷贝拉唑联合莫沙比利治疗反流性食管炎疗效观察

      作者：李诗海，陈瑛，张琴，刘杰锋，叶秀芳，冯丽英，郑柳青
    （东莞市塘厦医院消化内科，广东东莞523710）

      卷次： 2012年23卷5期

      【摘要】目的观察雷贝拉唑联合莫沙比利对反流性食管炎的治疗效果。方法选择我院诊治的反流性
食管炎患者462 例，根据随机的方法将患者分为观察组和对照组，观察组患者应用雷贝拉唑及莫沙比利，对照组
患者应用奥美拉唑。比较两组患者的内镜下疗效及治疗前后患者症状评分的变化。结果内镜下，观察组患者
中治愈42 例，好转164 例，无效25 例，总有效率为89.2%。对照组患者中治愈30 例，好转145 例，无效56 例，总有
效率为75.8%。观察组患者治疗总有效率明显高于对照组，两者间差异有统计学意义（P＜0.05）。两组患者治疗
后症状评分均明显降低，与治疗前比较，差异有统计学意义（P＜0.05）。观察组患者治疗后症状评分明显低于对
照组，两者间差异有统计学意义（P＜0.05）。结论雷贝拉唑联合莫沙比利对反流性食管炎有较好的治疗效果，
具有很高的临床应用价值。

      【关键词】雷贝拉唑；反流性食管炎；莫沙比利；治疗

      【中图分类号】R571 【文献标识码】A 【文章编号】1003—6350（2012）05—034—03
r>Rabeprazole combined mosapride in the treatment of reflux esophagitis.
LI Shi-hai, CHEN Ying, ZHANG Qin, LIU
Jie-feng, YE Xiu-fang, FENG Li-ying, ZHENG Liu-qing. Department of Gastroenterology, Tangxia Hospital of Dongguan
City, Dongguan 523710, Guangdong, CHINA
【Abstract】Objective To observe the effect of rabeprazole combined with mosapride in the treatment of reflux
esophagitis. Methods 462 reflux esophagitis patients were randomly divided into two groups. The patients in
the observation group were treated with rabeprazole and mosapride, while those in the control group were treated with
omeprazole. The efficacy under endoscopic and the symptom score were compared. Results There were 42 cases
cured, 164 cases improved, 25 cases ineffective in the observation group, with the total efficiency rate of 89.2%. There
were 30 cases cured, 145 cases improved, 56 cases ineffective in the control group, with the total efficiency rate of
75.8%. The total efficiency rate of the observation group was significantly higher than that of the control group, with a
statistically significant difference (P<0.05). The symptom score after treatment were significantly lower compared with
that before treatment, and there was a statistically significant difference (P<0.05). The patients symptom score after treatment
in the observation group was significantly lower than than in the control group, and there was a significant differences
between the two groups (P<0.05). Conclusion Rabeprazole combined mosapride have a better therapeutic effect
in the treatment of reflux esophagitis, with high clinical value.
【Key words】Rabeprazole; Reflux esophagitis; Mosapride; Treatment