标题：犬脑适应性再灌注的脑保护机制研究

      作者：陈辉清，甄 云，麦明霞，陈绮坚，黄振林，胡少杰
    (深圳宝安西乡人民医院，广东 深圳 518102)

      卷次： 2012年23卷5期

      【摘要】 目的 探讨崭新的改善灌注的方法—适应性再灌注的脑保护作用。方法 21只犬被随机分为三
组：对照组、常规再灌注组、适应性再灌注组，各7只。对犬的基本生命体征变化、血气指标、血清离子浓度进行实
时同步监测分析，并对缺血脑组织学变化及神经功能进行评价。结果 脑适应性再灌注对血气指标、电解质等
的影响小，能明显改善再灌注区的损伤神经元的功能及病理。结论 脑适应性再灌注是一种有效的脑保护作用
的灌注方式。

      【关键词】 失血性休克；脑缺血；复苏；再灌注；神经功能评分

      【中图分类号】 R-332 【文献标识码】 A 【文章编号】 1003—6350（2012）05—025—04<

br>Study on the cerebral protection effect of cerebral adapted reperfusion in canine.
CHEN Hui-qing, ZENG Yun,
MAI Ming-xia, CHEN Qi-jian, HUANG Zhen-lin, HU Shao-jie. Xixiang People's Hospital of Bao'an District of Shenzhen
City, Shenzhen, 518102, Guangdong, CHINA

【Abstract】 Objective To investigate the cerebral protection effect of cerebral adapted reperfusion.
Methods Twenty-one mongrel dogs were randomly divided into three groups: the control group, the routine reperfu-
sion group, and the adapted reperfusion group, each with 7 cases. The basic vital signs, blood gas, and electrophysio-
logical Changes were monitored and analyzed. The cerebral ischemic histology and neurological function were evalu-
ated. Results The cerebral adapted reperfusion has less impact on blood gas and electrophysiological Changes,
which was able to significantly improve the function of ischemic neurons and histologic damage. Conclusion Cere-
bral adapted reperfusion is a beneficial reperfusion style, which has neuroprotective effect.

      【Key words】 Hemorrhagic shock; Cerebral ischemia; Fluid resuscitation; Reperfusion; Neurological grade
基金项目：深圳市宝安区科技计划项目(编号：2009327)