标题：β-受体阻滞剂治疗婴幼儿血管瘤的研究进展

      作者：李忠达，彭智
    (广东医学院，广东 湛江 524023)

      卷次： 2016年27卷4期

      【摘要】 婴幼儿血管瘤(IH)是一种最常见的良性肿瘤，在婴幼儿中患病率为4%~10%，虽然有部分 IH存在自
然消退过程，但少数 IH仍需要有效治疗，以防止其对皮肤的损害，导致肢体功能障碍以及发生局部溃疡。自2008
年，普萘洛尔，一种非选择性β-受体阻滞剂被报道能高效治疗婴幼儿血管瘤之后，目前有约200篇文献报道β-受体阻
滞剂对 IH治疗存在全身性、局部性疗效及潜在毒性。基于以上发现，β-受体阻滞剂在治疗 IH中产生非常高的疗效并
得到了认可。与类固醇比较，即使β-受体阻滞剂在使用过程中产生一定的副作用，如果在治疗过程中得到适当监测，
其更加安全与优质。本文主要对近几年来β-受体阻滞剂治疗IH作用机制，不良反应，用法、用量做一综述。

      【关键词】 婴幼儿血管瘤；β-受体阻滞剂；普萘洛尔；噻吗洛尔

      【中图分类号】 R732.2 【文献标识码】 A 【文章编号】 1003—6350（2016）04—0600—04


Research progress of beta-blockers in the treatment of infantile hemangioma.
LI Zhong-da, PENG Zhi. Department
of Orthopedics, Guangdong Medical College, Zhanjiang 524023, Guangdong, CHINA
【Abstract】 Infantile hemangiomas (IH) are the most common tumors of infancy, with a prevalence of approxi-
mately 4~10% of infants. Although the natural history of IH is to spontaneously involute, a significant minority of IH re-
quire therapy with the aim to prevent disfigurement, functional impairment, or ulceration. In 2008, propranolol, a non-se-
lective beta (β)-blocker, was reported to be highly effective in treating IH. Since that time there have been more than 200
articles published regarding the efficacy and potential toxicity of β-blockers, both systemic and topical, for the treatment
of IH. Based on these findings, β-blockers appear to be highly effective in treating IH and are well tolerated, though side
effects have been reported. When therapy is appropriately monitored, β-blockers have been proven to be a safer and su-
perior alternative to systemic steroids. This paper mainly reviews the treatment of IH through beta-blockers in recent
years involving the mechanism, side effects, usage and dosage.

      【Key words】 Infantile hemangioma; Beta-blocker; Propranolol; Timolol
·综 述·
6350.2016.04.028