标题：玻璃体腔注射康柏西普联合复合式小梁切除术治疗新生血管性青光眼临床观察

      作者：周林，周岚
    (淮安市第二人民医院徐州医学院附属淮安医院眼科，江苏 淮安 223002)

      卷次： 2016年27卷4期

      【摘要】 目的 观察玻璃体腔注射康柏西普(Conbercept)联合复合式小梁切除术治疗新生血管性青光眼
(NVG)的临床疗效。方法 选取2014年1~12月在徐州医学院附属淮安医院眼科病区住院并确诊为NVG的22例
(22眼)患者，行玻璃体腔注射康柏西普(0.50 mg/0.05 ml)，8~14 d后行复合式小梁切除术。观察玻璃体腔注射康柏
西普后虹膜新生血管消退的时间，眼压的变化以及复合式小梁切除术后视力和眼压的变化。术后随访3~15个月。
结果 玻璃体腔注射康柏西普后，17只眼虹膜新生血管1周内完全消退，5只眼2周内完全消退。注药前平均眼压
(41.53±3.37) mmHg，注药后 1周平均眼压(40.12±2.13) mmHg，与注药前比较眼压变化差异无统计学意义(P>
0.05)。复合式小梁切除术后 1周眼压(11.43±1.68) mmHg，术后 1个月眼压(12.15±1.46) mmHg，术后 3个月眼压
(12.81±1.56) mmHg，最后一次随访眼压(12.03±2.31) mmHg，与术前比较差异均有统计学意义(P<0.05)。术后最佳
矫正视力>0.1者4眼，视力0.01~0.1者15眼，与术前视力比较，差异有统计学意义(P<0.05)。结论 玻璃体腔注射
康柏西普联合复合式小梁切除术能有效地控制眼压，保护视功能。

      【关键词】 新生血管性青光眼；玻璃体腔注射；康柏西普；复合小梁切除术；疗效

      【中图分类号】 R775.3 【文献标识码】 A 【文章编号】 1003—6350（2016）04—0591—03


Clinical observation of intravitreous injection of Conbercept combined with complex trabeculectomy in the
treatment for neovascular glaucoma.
ZHOU Lin, ZHOU Lan. Department of Ophthalmology, Huai'an Second People's
Hospital, Huai'an Hospital Affiliated to Xuzhou Medical College, Huai'an 223002, Jiangsu, CHINA

【Abstract】 Objective To observe the effect of intravitreous injection of Conbercept combined with complex
trabeculectomy on neovascular glaucoma (NVG). Methods Twenty-two eyes of 22 patients with NVG in our hospital
were treated with intravitreous injection of Conbercept (0.50 mg/0.05 ml) and then complex trabeculectomy 8~14 days
later. The regression of iris neovascularization and changes in intraocular pressure (IOP) were observed after injection．
Best corrected visual acuity and changes in IOP were observed after complex trabeculectomy. Patients were followed-up
for 3~15 months after operation. Results After injection of Conbercept, iris neovascularization completely regressed
within 1 week in 17 eyes and within 2 weeks in 5 eyes. The average IOP was (41.53±3.37) mmHg before injection and
(40.12±2.13) mmHg in a week after injection, showing no statistically significant difference (P>0.05). The IOP at 1 week,
1 month, 3 months after complex trabeculectomy were (11.43±1.68) mmHg, (12.15±1.46) mmHg, (12.81±1.56) mmHg,
and (12.03±2.31) mmHg in the last follow-up visit, showing statistically significant difference compared with those be-
fore trabeculectomy (P<0.05). After surgery, the best-corrected visual acuity was >0.1 in 4 eyes, 0.01~0.1 in 15 eyes,
which showed statistically significant difference with the visual acuity before surgery (P<0.05). Conclusion Intravitre-
ous injection of Conbercept combined with complex trabeculectomy can effectively control the IOP and preserve the vi-
sual function in patients with neovascular glaucoma.

      【Key words】 Neovascular glaucoma; Intravitreal injection; Conbercept; Complex trabeculectomy; Effect
·论 著·
6350.2016.04.025