标题：早产儿侵袭性真菌感染的危险因素及防治措施

      作者：马晓蕾
    (安康市中心医院新生儿科，陕西 安康 725000)

      卷次： 2016年27卷4期

      【摘要】 目的 分析早产儿侵袭性真菌感染(IFI)的危险因素，并探讨其相应的防治措施。方法 选择2013年
10月至2015年2月我院收治的1 847例早产儿中发生 IFI的64例患儿的临床资料，分析其发生真菌感染的危险因
素。结果 1 847例早产儿中有64例被诊断为 IFI，感染率为3.47%，其中真菌感染种类以假丝酵母菌多见。感染部位
口腔>肺>脑。胎龄≤32周、胎儿体重≤1.5 kg、住院时间>2周、静脉营养时间>1周、辅助机械通气、使用广谱抗生素及
产妇伴有妊娠合并症者早产儿 IFI的发生率，均高于同组的其他数据，差异均有统计学意义(P<0.05)。胎儿体重、辅助
机械通气、使用广谱抗生素和静脉营养时间均为早产儿 IFI的独立高危因素。结论 胎龄小、胎儿体重低、住院时间和
静脉营养时间长、辅助机械通气、使用广谱抗生素及产妇伴有妊娠合并症都是早产儿 IFI的危险因素，以上因素都会增
加早产儿IFI的发生率。因此加强预防并制定出有效的控制措施对降低早产儿IFI的发生率至关重要。

      【关键词】 早产儿；侵袭性真菌感染；危险因素；防治

      【中图分类号】 R722 【文献标识码】 A 【文章编号】 1003—6350（2016）04—0586—03


Risk factors and preventive measures of invasive fungal infection in premature infants.
MA Xiao-lei. Department of
Neonatology, Ankang Central Hospital, Ankang 725000, Shaanxi, CHINA

【Abstract】 Objective To analyze the risk factors of invasive fungal infections (IFI) in premature infants, and to
explore the corresponding prevention and treatment measures. Methods The clinical data of 64 patients of IFI from
1 847 premature infants in our hospital from October 2013 to February 2015 were collected, and the risk factors of fungal
infection were analyzed. Results Among the 1 847 premature infants, 64 were diagnosed as IFI, with the infection rate of
3.47%. The type of fungal infection was mainly Candida albicans, and the infected areas were commonly oral cavity, and
then lung, brain. The infants with gestational age≤32 weeks, fetal weight≤1.5 kg, length of hospital stay >2 weeks, in-
travenous nutrition time >1 week, assisted mechanical ventilation, use of broad-spectrum antibiotics, and those whose
mother had pregnancy complications tended to have higher incidence of IFI than other infants in the same group. The dif-
ferences were statistically significant (P<0.05). Fetal weight, assisted mechanical ventilation, use of broad-spectrum antibi-
otics and intravenous nutrition were the independent risk factors of IFI in premature infants. Conclusion Small gesta-
tional age, low birth weight, long length of hospital stay and long intravenous nutrition time, assisted mechanical ventila-
tion, use of broad-spectrum antibiotics and pregnancy complications are the risk factors of IFI in premature infants,
which increase the incidence of IFI. Therefore, it is very important to strengthen the prevention and control measures to
reduce the incidence of IFI in premature infants.

      【Key words】 Premature infant; Invasive fungal infection (IFI); Risk factors; Prevention and control
·论 著·
6350.2016.04.023