标题：易误诊的胃无色素恶性黑色素瘤一例

      作者：张强，郭瑶瑶，邱泽兵，白晓英    大英县人民医院病理科，四川 大英 629300

      卷次： 2024年35卷10期

      【摘要】 恶性黑色素瘤是来源于黑色素细胞的恶性转化，而这些产生黑色素的细胞胚胎来自多潜能的神经嵴干细胞。胃内缺乏黑色素细胞，黑色素瘤在此部位原发及转移均罕见。当缺乏色素时极易误诊为癌、淋巴瘤等肿瘤。现报告一例胃镜呈小息肉样改变，活检成分由弥漫一致低黏附性无色素异型细胞构成，免疫组化证实为恶性黑色素瘤，符合转移但原发灶不明的病例诊断。该报道并文献复习旨在提高对该部位罕见肿瘤的临床病理特征认识，避免误诊和漏诊。
      【关键词】 胃无色素恶性黑色素瘤；临床病理特征；病理检查
      【中图分类号】 R735.2 【文献标识码】 D 【文章编号】 1003—6350（2024）10—1485—04

A case of easily misdiagnosed gastric amelanotic malignant melanoma.
ZHANG Qiang, GUO Yao-yao, QIU Ze-bing,BAI Xiao-ying. Department of Pathology, Daying County People's Hospital, Daying 629300, Sichuan, CHINA【Abstract】 Malignant melanoma is derived from malignant transformation of melanocytes, and these melano-ma-producing cell embryos are derived from pluripotent neural crest stem cells. Due to lack of melanocytes in the stom-ach, both primary and metastatic melanoma are rare in this area. When lack of pigment, it is easily misdiagnosed as can-cer, lymphoma or other tumors. This paper reports a case of small polypoid change in gastroscopy, and biopsy compo-nents consist of diffuse and consistent low-adhesion non-pigmentary heterotypic cells. Immunohistochemistry confirmedthat it is a malignant melanoma, which is consistent with the case of metastasis but unknown primary focus. This reportaims to improve the understanding of the clinicopathological features of rare tumors in this site and avoid misdiagnosisand missed diagnosis.
      【Key words】 Gastric amelanotic malignant melanoma; Clinicopathological features; Pathological examination